In vitro combination of voriconazole with micafungin against azole-resistant clinical isolates of Aspergillus fumigatus from different geographical regions.

Hamed Fakhim Afsane Vaezi Eric Dannaoui Cheshta Sharma Bita Mousavi Anuradha Chowdhary Jacques F Meis Hamid Badali

Diagn Microbiol Infect Dis

Department of Medical Mycology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran; Pharmaceutical Sciences Research Center, Hemoglobinopathy Institute, Mazandaran University of Medical Sciences, Sari, Iran. Electronic address:

Published: July 2018

In vitro interaction of voriconazole with micafungin was evaluated against 33 clinical Aspergillus fumigatus isolates, including azole-resistant (n=31) and -susceptible (n=2) isolates. Interaction was synergistic for only 1 resistant isolate carrying the TR/L98H mutation. No antagonistic effects were observed for 96.8% of azole-resistant isolates.

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http://dx.doi.org/10.1016/j.diagmicrobio.2018.03.003	DOI Listing

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