AI Article Synopsis
- The regulation of body temperature is essential for mammalian health, and this review highlights how the nervous system manages this critical function.
- Researchers explore the molecules and cells responsible for detecting temperature in the body, the communication pathways to the brain, and how the brain coordinates responses to maintain temperature balance.
- The review also identifies unresolved questions in the field, such as how the brain senses temperature and the specifics of cold and warm sensors, while emphasizing that advanced circuit analysis methods could lead to new discoveries.
Article Abstract
The regulation of body temperature is one of the most critical functions of the nervous system. Here we review our current understanding of thermoregulation in mammals. We outline the molecules and cells that measure body temperature in the periphery, the neural pathways that communicate this information to the brain, and the central circuits that coordinate the homeostatic response. We also discuss some of the key unresolved issues in this field, including the following: the role of temperature sensing in the brain, the molecular identity of the warm sensor, the central representation of the labeled line for cold, and the neural substrates of thermoregulatory behavior. We suggest that approaches for molecularly defined circuit analysis will provide new insight into these topics in the near future.
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Source |
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6034117 | PMC |
| http://dx.doi.org/10.1016/j.neuron.2018.02.022 | DOI Listing |
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