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Exploring peptide dendrimers for intestinal lymphatic targeting: formulation and evaluation of peptide dendrimer conjugated liposomes for enhancing the oral bioavailability of Asenapine maleate.
Sci Rep
November 2024
Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, Karnataka, 576104, India.
Article Synopsis
- Asenapine maleate (ASPM) is a second-generation antipsychotic approved for adult schizophrenia and bipolar disorder but suffers from low oral bioavailability (<2%) due to extensive first-pass metabolism in the liver.
- To improve ASPM's absorption, researchers developed nanoformulations using ligands like RGD and peptide dendrimers to target the intestinal lymphatic system.
- Various techniques, including solid phase peptide synthesis and high-performance chromatography, were used to create and characterize liposomal formulations, and in vitro and in vivo studies were conducted to assess their effectiveness and pharmacokinetics in rats.
Comparison of oven drying and freeze drying methods for the production of fast melt films containing quetiapine fumarate.
Drug Dev Ind Pharm
September 2024
Faculty of Pharmacy, University of Cyberjaya, Cyberjaya,Malaysia.
Background: Quetiapine fumarate (QTP) is commonly prescribed for schizophrenic patient, typically available in tablet or oral suspension form, presenting challenges such as administration difficulties, fear of choking and distaste for its bitter taste. Fast melt films (FMF) offer an alternative dosage form with a simple development process, ease of administration and rapid drug absorption and action onset.
Objective: This study aims to prepare FMF with different formulations using solvent casting methods and to compare the effects of different drying methods, including oven drying and freeze drying, on the properties of the films.
Ocular toxicity of psychotropic medications in a tertiary hospital in Lagos, Nigeria.
Rom J Ophthalmol
July 2024
Department of Behavioural Medicine, Lagos State University College of Medicine, Lagos State, Nigeria.
Article Synopsis
- * Various eye exams revealed additional problems: 20.3% showed lid pigmentation, 32.2% had cataracts, and 4.2% experienced peripheral retina degeneration, while Schirmer's test indicated varying levels of dry eyes among participants.
- * The research highlighted that long-term use and higher doses of psychotropic drugs could lead to serious eye-related side effects, affecting patients' overall quality of life and necessitating preventive measures against visual impairment.
Chlorpromazine-Polypyrrole Drug Delivery System Tailored for Neurological Application.
Molecules
March 2024
Department of Materials and Ceramic Engineering, Centre for Research in Ceramics and Composite Materials (CICECO), University of Aveiro, Campus de Santiago, 3810-193 Aveiro, Portugal.
Nowadays, drug delivery systems (DDSs) are gaining more and more attention. Conducting polymers (CPs) are efficiently used for DDS construction as such systems can be used in therapy. In this research, a well-known CP, polypyrrole (PPy), was synthesized in the presence of the polysaccharide heparin (HEP) and chlorpromazine (CPZ) using sodium dodecyl sulfate (SDS) as electrolyte on a steel substrate.
View Article and Find Full Text PDFPredicting the Kinetics of Resupply of Organic Pollutants from Sediments Using Diffusive Gradients in Thin Film Samplers and their Bioavailability to Aquatic Invertebrates.
Environ Toxicol Chem
August 2023
School of Environment and Sustainability, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.
The present study used diffusive gradients in thin film (DGT) samplers deployed in situ at a wastewater-impacted site (Clarkboro Ferry) for 20 days to develop a predictive model between time-weighted mean concentrations of seven selected antipsychotic compounds in water and those in resident benthic invertebrates, specifically crayfish (Faxonius virilis). The model was further combined with a model of desorption of antipsychotic compounds to predict kinetics at the sediment-water interface. Antipsychotic compounds were mostly detected in adult crayfish and internal concentrations were similar among targeted compounds, except for lesser concentrations of duloxetine.
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