AI Article Synopsis
- This study investigates the link between specific gene variations (polymorphisms) in the TRPV1 and TRPA1 genes and pain crises in patients with sickle cell disease (SCD).
- It uses the number of emergency room visits within a year due to acute pain as a measure of pain severity.
- Findings suggest that certain polymorphisms in the TRPA1 gene are significantly linked to increased pain crises, indicating potential targets for better pain management in SCD patients.
Article Abstract
Aim: Episodes of acute pain crisis contribute to considerable morbidity and mortality in sickle cell disease (SCD). Incomprehensive understanding of the underlying pain heterogeneity results in inadequate pain management. The transient receptor potential (TRP) family of voltage-gated ion channels acts as sensory transducers of diverse noxious stimuli. We performed an association study of polymorphisms in candidate genes TRPV1 and TRPA1 with pain in SCD patients.
Methods: Utilization rate, in other words, number of emergency department/acute care center admissions over 12 months as a result of pain crisis, served as a marker for acute pain.
Results & Conclusion: We identified that rs920829 (incident rate ratio = 1.44, p = 0.027 additive; IRR=1.68, p=0.008 recessive models of negative binomial regression) and the CGAGG haplotype of TRPA1 (odds ratio = 0.218, p = 0.009) were significantly associated with utilization rate, suggesting that TRPA1 gene polymorphisms may influence acute pain crisis in SCD.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6275563 | PMC |
| http://dx.doi.org/10.2217/pgs-2017-0198 | DOI Listing |
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