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Background: AML-M4Eo is a type of AML characterized by malignant proliferation of granulocyte and monocyte precursor cells accompanied by eosinophilia. Patients present as anemia, infection, bleeding, and tissue and organ infiltration. MICM classification makes the classification of AML more accurate and lays a foundation for the correct treatment and prognosis of AML.
View Article and Find Full Text PDFThe outcome of functional constipation in Saudi children.
Turk J Pediatr
December 2024
Gastroenterology Division, Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Kingdom of Saudi Arabia.
Background: Understanding the outcome of functional constipation (FC) for both patients and physicians is essential, yet it has been infrequently reported worldwide. The objective of this report was to update the outcomes of FC in Saudi children.
Methods: Clinical data including age, sex, response to management, duration of follow up, and type of management were collected from the notes of each clinic visits and phone call follow-ups.
The role of CNBP in brain atrophy and its targeting in myotonic dystrophy type 2.
Hum Mol Genet
January 2025
Division of Neurology, Cincinnati Children's Hospital, 3333 Burnet Ave, Cincinnati, OH 45229, United States.
Myotonic Dystrophy type 2 (DM2) is a multisystem disease affecting many tissues, including skeletal muscle, heart, and brain. DM2 is caused by unstable expansion of CCTG repeats in an intron 1 of a gene coding for cellular nuclear binding protein (CNBP). The expanded CCTG repeats cause DM2 pathology due to the accumulation of RNA CCUG repeats, which affect RNA processing in patients' cells.
View Article and Find Full Text PDFNeurological Soft Signs in Type I Bipolar Disorder and Bipolar Spectrum Patients and Their Unaffected First-Degree Relatives: A Cross-Sectional Study.
Health Sci Rep
January 2025
School of Medicine, Behavioral Science Research Center of Imam Hossein Hospital Shahid Beheshti University of Medical Sciences Tehran Iran.
Background And Aims: This study aimed to compare neurological soft signs (NSSs) in type 1 bipolar disorder (BD), bipolar spectrum (BS) patients, and their unaffected first-degree relatives.
Methods: This descriptive cross-sectional study involved participants referred to the Psychiatric Department of Imam Hossein Hospital. Five groups ( = 25): patients with type 1 BD, patients with BS, unaffected first-degree relatives of the two groups, and a control group were evaluated using the Neurological Evaluation Scale (NES).
Heart Rate and Blood Pressure Responses Vary Between Blood Flow Restriction Cuff Type.
Int J Exerc Sci
December 2024
Exercise Science, Florida Southern College, Lakeland, FL, USA.
The purpose of the study was to compare heart rate (HR), systolic blood pressure (SBP), and diastolic blood pressure (DBP) following high load resistance exercise (HLRE) and blood flow restriction exercise (BFRE) with a knee wrap (kBFRE) and pneumatic cuff (pBFRE). Eleven men (N = 9) and women (N = 2) participated. HR, SBP, and DBP were collected at Rest, immediately post exercise (IP), 10-, 30-, and 45-minutes post exercise.
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