AI Article Synopsis
- * Patients receiving intensive therapies like azacytidine or stem cell transplants had the longest median survivals, ranging from 9 to 19.4 months.
- * The study suggests that early diagnosis of accelerated phases and considering intensive treatment for eligible patients can enhance survival outcomes, while supportive care might be better suited for older patients or those with poor genetic markers.
Article Abstract
Myeloproliferative neoplasms (MPN) are chronic disorders that can sometimes evolve into accelerated or leukemic phases. We retrospectively identified 122 patients with such blastic phases. The overall median survival was four months: 10.2 months for patients treated with intensive treatments compared to three months for best supportive care (p = .005). Azacytidine, intensive chemotherapies, or allogeneic stem cell transplantation gave the highest median survivals with 9, 10.2, and 19.4 months, respectively. Accelerated phases (AP) had a longer median survival compared to acute leukemia (4.8 months vs. 3.1 months; p = .02). In this retrospective and observational study, we observe that the longest survivals are seen in patients eligible for intensive treatments. Azacytidine shows interesting results in patients non-fit for intensive chemotherapy. Supportive care should probably be restricted to elderly patients and those with unfavorable karyotype. An early diagnosis of AP could also result in a better survival rate.
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| http://dx.doi.org/10.1080/10428194.2018.1441408 | DOI Listing |
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