A diagnosis of asbestosis, which is a long-latency, fibrotic lung disease, has implications for the patient in terms of prognosis, treatment and compensation. Identifying and quantifying asbestos exposure is difficult without a detailed occupational history, and the threshold dose of asbestos required to cause asbestosis is not well understood. We reviewed all cases of asbestosis diagnosed between 2001 and 2016 at the Birmingham Regional NHS Occupational Lung Disease Service to determine the industries and occupations most frequently implicated in causation, in order to help clinicians identify where asbestosis might enter the differential diagnosis for a patient with chronic respiratory symptoms. A variety of construction trades were frequently reported including carpenters and joiners, pipe fitters, laggers, labourers, painters and shop fitters. Traditionally heavily exposed occupations such as shipbuilding were not commonly seen.
Download full-text PDF |
Source |
---|---|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5882659 | PMC |
http://dx.doi.org/10.1038/s41533-018-0078-6 | DOI Listing |
BMC Plant Biol
January 2025
Academy of Agricultural and Forestry Sciences, Qinghai University, Xining, 810016, China.
Barley leaf stripe, a disease mainly caused by Pyrenophora graminea (P. graminea) infection, severely affects barley yield and quality and is one of the most widespread diseases in barley production. However, little is known about the underlying molecular mechanisms of leaf stripe resistance.
View Article and Find Full Text PDFMol Immunol
January 2025
Department of Cell Biology, School of Preclinical Medicine, Zunyi Medical University, Zunyi, Guizhou 563003, China. Electronic address:
Background: Midges are widely distributed globally. They can transmit numerous serious diseases as well as trigger an allergic reaction in the host. Their saliva contains a variety of proteins that act as sensitizers to stimulate the host's immune response, leading to IgE-mediated allergic symptoms.
View Article and Find Full Text PDFChemistry
January 2025
East China Normal University, Shanghai Key Laboratory of Green Chemistry and Chemical Process, 3663 North Zhongshan Road, 200062, Shanghai, CHINA.
Polysulfides play an essential role across a variety of fields, including life sciences, pharmaceuticals, food science, and materials science. However, the controlled sequential installation of groups at both ends of an S-S motif poses enormous challenges due to the reversible nature of the covalent S-S bond. The application of unique disulfide reagents presents one of the most straightforward approaches for constructing diverse polysulfides.
View Article and Find Full Text PDFBiofabrication
January 2025
Polymer Chemistry and Biomaterials (PBM) Group, Centre of Macromolecular Chemistry (CMaC), Department of Organic and Macromolecular Chemistry, Ghent University, Krijgslaan 281, Gent, 9000, BELGIUM.
Volumetric bioprinting has revolutionized the field of biofabrication by enabling the creation of cubic centimeter-scale living constructs at faster printing times (in the order of seconds). However, a key challenge remains: developing a wider variety of available osteogenic bioinks that allow osteogenic maturation of the encapsulated cells within the construct. Herein, the bioink exploiting a step-growth mechanism (norbornene-norbornene functionalized gelatin in combination with thiolated gelatin - GelNBNBSH) outperformed the bioink exploiting a chain-growth mechanism (gelatin methacryloyl - GelMA), as the necessary photo-initiator concentration was three times lower combined with a more than 50 % reduction in required light exposure dose resulting in an improved positive and negative resolution.
View Article and Find Full Text PDFQ Rev Biophys
January 2025
Institute of Synthetic Bioarchitectures, Department of Bionanosciences, University of Natural Resources and Life Sciences, Vienna, Austria.
Prokaryotic microorganisms, comprising and , exhibit a fascinating diversity of cell envelope structures reflecting their adaptations that contribute to their resilience and survival in diverse environments. Among these adaptations, surface layers (S-layers) composed of monomolecular protein or glycoprotein lattices are one of the most observed envelope components. They are the most abundant cellular proteins and represent the simplest biological membranes that have developed during evolution.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!