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Preparation and In Vitro/In Vivo Characterization of Mixed-Micelles-Loaded Dissolving Microneedles for Sustained Release of Indomethacin.
Pharmaceutics
November 2024
Department of Pharmaceutics, School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou Higher Education Mega Center, 280 East Waihuan Road, Guangzhou 510006, China.
Indomethacin (IDM) is commonly used to treat chronic inflammatory diseases such as rheumatoid arthritis and osteoarthritis. However, long-term oral IDM treatment can harm the gastrointestinal tract. This study presents a design for encapsulating IDM within mixed micelles (MMs)-loaded dissolving microneedles (DMNs) to improve and sustain transdermal drug delivery.
View Article and Find Full Text PDFLaser-Based Length-Measuring Board for the Measurement of Infant Body Length from Outside an Incubator: Proposal and Assessment of a Model.
Children (Basel)
December 2024
Instituto de Plasmas e Fusão Nuclear, Instituto Superior Técnico, Universidade de Lisboa, 1049-001 Lisbon, Portugal.
Introduction: Opening the incubator side wall to insert a non-sterile length-measuring device carries the risk of microbial contamination and thermal instability for preterm infants. To reduce this inconvenience, a laser-based length-measuring board is proposed to measure body length from outside the incubator.
Methods: This device has two laser-line-shaped cursors which can be pointed to opposite ends of a segment to be measured.
Efficacy of the reGENER@r Program on Socio-Emotional Skills and Sexist Beliefs in Perpetrators of Gender-Based Violence: A Pilot Study in Spain.
Behav Sci (Basel)
December 2024
Mind, Brain and Behavior Research Center (CIMCYC), University of Granada, Campus Universitario de Cartuja, 18011 Granada, Spain.
Background: Gender-based violence (GBV) is one of the most pronounced expressions of the unequal power relations between women and men. As a tool for action against this phenomenon, psychological intervention programs for perpetrators of GVB are offered. This is how reGENER@r was born; it is a two-month program based on psychoeducational and cognitive-behavioral strategies that is part of the alternative measures to GBV-related prison sentences.
View Article and Find Full Text PDFFull-Endoscopic J-Shaped Transforaminal L5 Nerve Decompression in Bertolotti Syndrome.
Neurospine
December 2024
Department of Neurosurgery, Chosun University Hospital, Gwangju, Korea.
This case report and video demonstrate the technique of full-endoscopic J-shaped transforaminal L5 exiting nerve decompression in Bertolotti syndrome. Bertolotti syndrome, characterized by a congenital lumbosacral transitional vertebra, often results in mechanical lower back pain and nerve root compression. A 69-year-old male presented with progressive radiating pain in the right leg and tingling in the L5 dermatome.
View Article and Find Full Text PDFA point mutation in the pepper veinal mottle virus 6K1 protein yields a stable attenuated strain for engineering virus resistance in pepper plants.
Plant Dis
January 2025
No. 58, Renmin AvenueHaikou, China, 570228;
A total of 164 viruses have been identified in peppers worldwide. To combat viruses, pathogen-derived resistance (PDR) has been employed by expressing a viral genomic segment or a viral protein in host plants. Unfortunately, peppers are recalcitrant to genetic transformation and regeneration.
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