Comparison of Mean Corneal Endothelial Cell Loss after Trabeculectomy with and without Mitomycin C.

Objective: To compare mean endothelial cell loss in patients of primary open angle glaucoma undergoing trabeculectomy with and without mitomycin C.

Study Design: Randomised control study.

Place And Duration Of Study: Institute of Ophthalmology, Mayo Hospital, Lahore, from May 2016 to April 2017.

Methodology: Patients with primary open angle glaucoma, not controlled with medication, were selected from the outpatient department. Patients with secondary glaucomas and concomitant ocular disease were excluded. Selected patients were divided into two groups of 30 each. Group A patients underwent trabeculectomy with adjunctive mitomycin C while group B patients underwent trabeculectomy alone. Pre- and post-trabeculectomy endothelial cell counts were recorded with the help of specular microsope and entered on proforma.

Results: Median cell loss was 283 (66.50) when trabeculectomy was done with the use of adjunctive mitomycin C in group A while median endothelial cell loss was 72.50 (19.25) when the trabeculectomy was done without the use of adjunctive mitomycin C in group B.

Conclusion: Use of mitomycin C causes more endothelial cell loss during trabeculectomy as compared to when done without it.