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Impact of hematopoietic stem cell transplantation in patients with relapsed or refractory mantle cell lymphoma. | LitMetric

AI Article Synopsis

  • Rituximab improves outcomes for B-cell lymphoma patients, but relapsed or refractory mantle cell lymphoma (MCL) remains challenging due to poor prognosis.
  • A study analyzed 162 R/R MCL patients who underwent either autologous or allogeneic hematopoietic cell transplantation (HCT) from 2004 to 2014, showing median overall survival of 48 months for autologous HCT and 65 months for allogeneic HCT.
  • Risk factors for overall survival included older age, higher comorbidity scores, and specific treatment regimens for autologous HCT, while better performance status and longer diagnosis-to-treatment intervals were important for allogeneic HCT, suggesting a need

Article Abstract

Rituximab has been shown to improve outcomes in patients with B-cell lymphoma. However, patients with relapsed or refractory (R/R) mantle cell lymphoma (MCL) still have a poor prognosis, and the choice between high-dose therapy with autologous hematopoietic cell transplantation (HCT) and allogeneic HCT remains controversial in these patients. We retrospectively analyzed the risk factors for outcomes in 162 R/R MCL patients who received autologous (n = 111) or allogeneic (n = 51) HCT between 2004 and 2014. The median overall survival (OS) rates were 48 and 65 months in the autologous and allogeneic HCT groups, respectively (P = 0.20). Significant risk factors for overall survival in R/R MCL patients after autologous HCT were > 60 years of age at HCT (P = 0.017), higher score of HCT-specific comorbidity index at HCT (P = 0.033), and receiving MCEC (ranimustine + carboplatin + etoposide + cyclophosphamide) regimen (P = 0.017), while higher performance status at HCT (P = 0.011) and longer interval from diagnosis to HCT (P = 0.0054) were risk factors after allogeneic HCT. Strategies that carefully select R/R MCL patients for autologous HCT may allow the identification of individuals suitable for allogeneic HCT.

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Source
http://dx.doi.org/10.1007/s00277-018-3318-5DOI Listing

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