AI Article Synopsis
- The emergence of African swine fever virus (ASFV) in Russia and the Caucasus poses a significant risk to EU countries, highlighting the need for improved research and defense strategies.
- The ASFV genome has several non-essential genes that help the virus evade the host's immune system, including those that affect inflammation and apoptosis, which may contribute to the virus's virulence.
- Researchers are developing potential live attenuated vaccine (LAV) prototypes by creating recombinant NH/P68 viruses that lack these key immune evasion genes while including specific markers for tracking.
Article Abstract
The risk of spread of African swine fever virus (ASFV) from Russia and Caucasian areas to several EU countries has recently emerged, making it imperative to improve our knowledge and defensive tools against this important pathogen. The ASFV genome encodes many genes which are not essential for virus replication but are known to control host immune evasion, such as NFκB and the NFAT regulator A238L, the apoptosis inhibitor A224L, the MHC-I antigen presenting modulator EP153R, and the A276R gene, involved in modulating type I IFN. These genes are hypothesized to be involved in virulence of the genotype I parental ASFV NH/P68. We here describe the generation of putative live attenuated vaccines (LAV) prototypes by constructing recombinant NH/P68 viruses lacking these specific genes and containing specific markers.
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| http://dx.doi.org/10.1016/j.vaccine.2018.03.040 | DOI Listing |
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