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Single-Cell Transcriptomic Analysis of Tumor Heterogeneity. | LitMetric

Single-Cell Transcriptomic Analysis of Tumor Heterogeneity.

Trends Cancer

Department of Systems Biology, Columbia University Medical Center, New York, NY 10032, USA; Department of Biochemistry and Molecular Biophysics, Columbia University Medical Center, New York, NY 10032, USA; Sulzberger Columbia Genome Center, Columbia University Medical Center, New York, NY 10032, USA. Electronic address:

Published: April 2018

AI Article Synopsis

  • - Intratumoral heterogeneity makes it difficult to effectively treat cancer with precision therapies.
  • - High-throughput single-cell RNA sequencing (scRNA-seq) advancements offer new ways to analyze the different cell types within tumors.
  • - These technologies could help in choosing the right targeted therapies and determining eligibility for clinical trials in the future.

Article Abstract

Intratumoral heterogeneity is among the greatest challenges in precision cancer therapy. However, developments in high-throughput single-cell RNA sequencing (scRNA-seq) may now provide the statistical power to dissect the diverse cellular populations of tumors. In the future these technologies might inform the selection of targeted combination therapies and enrollment criteria for clinical trials.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5993208PMC
http://dx.doi.org/10.1016/j.trecan.2018.02.003DOI Listing

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