Mechanical thrombectomy: a comparison of two rotational devices and balloon angioplasty in subacute canine femoral thrombosis.

In this study, two prototype rotational devices were compared to balloon angioplasty in a canine model of subacute arterial thrombosis. Radiographic 2- to 8-day-old total thrombotic occlusions were produced in 30 canine femoral arteries. A high-speed rotating device with a cutting tip was used in 18 arteries. Successful opening occurred in every case, with a residual percent diameter stenosis at 45 +/- 25%. Vessel perforation was seen in 6 of the 18 arteries. A noncutting rotational thrombectomy catheter was used in six arteries. Radiographic patency was established in two of six (residual stenosis 86 +/- 28%), with one perforation with the use of the noncutting thrombectomy catheter. Balloon angioplasty reestablished radiographic patency in three of six arteries (residual stenosis 77 +/- 2%). No perforations were seen with balloon dilation, but radiographic distal emboli were always observed. No radiographic emboli were observed with either of the rotational devices. We conclude that subacute arterial thromboses are easily opened with an abrasive-tipped rotating angioplasty device. Although perforations are relatively common with this prototype equipment, design changes may produce a clinically useful angioplasty device.