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| http://dx.doi.org/10.18240/ijo.2018.03.28 | DOI Listing |
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Association between choroidal microvasculature in the eye and Alzheimer's disease risk in cognitively healthy mid-life adults: A pilot study.
Alzheimers Dement (Amst)
January 2025
Introduction: We explored associations between measurements of the ocular choroid microvasculature and Alzheimer's disease (AD) risk.
Methods: We measured the choroidal vasculature appearing in optical coherence tomography (OCT) scans of 69 healthy, mid-life individuals in the PREVENT Dementia cohort. The cohort was prospectively split into low-, medium-, and high-risk groups based on the presence of known risk factors (apolipoprotein E [] ε4 genotype and family history of dementia [FH]).
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Methods Mol Biol
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Centre for Developmental Neurobiology, King's College London, London, UK.
The choroid plexus (ChP) is a vital brain structure that produces cerebrospinal fluid (CSF) and forms a selective barrier between the blood and CSF, essential for brain homeostasis. Composed of secretory epithelial cells, connective stroma, and a fenestrated vascular network, the ChP supports nutrient transport, immune surveillance, and the clearance of toxic by-products. Despite its significance in maintaining cerebral function, the mechanisms underlying its development and maturation remain poorly understood.
View Article and Find Full Text PDFComment on: Subretinal Gene Therapy for Treatment of Retinal and Choroidal Vascular Diseases.
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Northern Lights Neuroscience Symposium 2024: Expanding Spectrum of Common Dementia Disorders.
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View Article and Find Full Text PDFHigh dynamic range widefield fundus photography with transcranial illumination: a contrast agent-free method for non-mydriatic choroidal imaging.
Biomed Opt Express
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Department of Biomedical Engineering, University of Illinois Chicago, Chicago, IL 60607, USA.
The choroid, a critical vascular layer beneath the retina, is essential for maintaining retinal function and monitoring chorioretinal disorders. Existing imaging methods, such as indocyanine green angiography (ICGA) and optical coherence tomography (OCT), face significant limitations, including contrast agent requirements, restricted field of view (FOV), and high costs, limiting accessibility. To address these challenges, we developed a nonmydriatic, contrast agent-free fundus camera utilizing transcranial near-infrared (NIR) illumination.
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