Background: The main objective of endodontic therapy is complete elimination and prevention of bacteria from the root canal system; however, it is difficult due to anatomical ramifications of root canal system and growing resistant microbes to available disinfectants. Therefore, to overcome this problem, newer antimicrobial agents have to be developed.
Aims: The aim of the study was to evaluate the antibacterial efficacy of fungal-derived biosynthesized silver nanoparticles (AgNPs) against .
Materials And Methods: Freshly prepared silver nanoparticles using the endophytic fungi , characterized by different techniques were used to evaluate the antibacterial efficacy against by agar well diffusion method measuring the zone of inhibition using different concentrations of nanoparticles (AgNPs) (A [20 μl], B [40 μl], C [60 μl], D [80 μl], and E [100 μl]), (0.2% chlorhexidine [CHX]), G (2% CHX), H (ampicillin), and I (distilled water) were used as control groups. Statistical Analysis Used: One-way ANOVA followed by Tukey multiple comparison test was done.
Results: AgNPs (100 ml) showed highest zone of inhibition 19.5 mm against . CHX (0.2%) 14.52 mm, CHX (2%) 20.02 mm, and ampicillin showed highest mean zone of inhibition 20.5 mm and distilled water showed no zone of inhibition. Results indicate no significant difference between E (100 μl), G (2% CHX), and H (ampicillin) ( < 0.0001).
Conclusions: Biosynthesized AgNPs exhibit efficient antibacterial activity against and therefore can be used as root canal irrigant or intracanal medicament for root canal disinfection.
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| http://dx.doi.org/10.4103/ccd.ccd_703_17 | DOI Listing |
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