Ten substituted 1,3-dihydroxyxanthones were synthesized in one step. The yields ranged from 40 to 76%. Compounds 8-10 were first reported. Next, the compounds' in vitro anti-proliferative activities against nine human cancer cell lines, antityrosinase, and antioxidant activities were evaluated. Compounds 1, 4, 6-7, and 9-10 exhibited enhanced cytotoxicity against certain cancer cells. Compounds 2, 8, 9, and 10 inhibited tyrosinase activity to a certain extent. In addition, compound 4 exhibited the best antioxidant activity, which was consistent with theoretical calculations. These results demonstrated that compounds 1-2, 4, and 6-10 were promising leads for further investigation.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1080/10286020.2018.1454437 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Background And Purpose: Many studies have been performed to identify new sources, their optimal isolation, and the biological activities of flavonoids due to nutraceutical, pharmaceutical, and cosmeceutical properties.
Experimental Approach: This review describes the method for flavonoid isolation and characteristic from the genus and their biological activities with the indication of the most active ones. To perform a comprehensive review, a thorough literature review using Google Scholar, Scopus, and Science Direct was performed with keyword alone or in combination with other words.
Application of Microwave-Assisted Water Extraction (MAWE) to Fully Realize Various Physiological Activities of Leaf Extract.
Plants (Basel)
November 2024
Graduate Institute of Applied Science and Engineering, Fu Jen Catholic University, New Taipei City 242062, Taiwan.
is widely grown in tropical areas worldwide. Studies have demonstrated that extracts of its buds, leaves, and branches obtained through hydrodistillation, steam distillation, or solvent extraction exhibit physiological activities, including anti-melanogenic, antibacterial, and antioxidant properties; nevertheless, such extracts are mostly not effectively collected or adequately utilized. Accordingly, this study applied a rapid, effective, and easy-to-operate microwave-assisted water extraction (MAWE) technique for the first time to prepare leaf extract (MLE) with improved physiological activities.
View Article and Find Full Text PDFCharacterization of the chemical profiles and biological activities of Thesium bertramii Azn. Extracts using a combination of in vitro, in silico, and network pharmacology methods.
Fitoterapia
December 2024
Department of Medical Biochemistry, Faculty of Medicine, Harran University, Sanliurfa, 63290, Turkey.
The genus Thesium, family Santalaceae, comprises about 350 species, and, although many of them are used as functional food and in traditional medicine, there are limited studies evaluating their pharmacological potential. The present study was designed to evaluate the chemical profile, antioxidant, and enzyme inhibition potential of aerial parts and roots of T. bertramii Azn.
View Article and Find Full Text PDFStructural and mechanistic insights into the anti-tyrosinase, anti-melanogenesis, and anti-browning effect of proanthocyanidins from seed coats of Acer truncatum Bunge.
Int J Biol Macromol
January 2025
College of Chemical and Biological Engineering, Yichun University, Yichun 336000, China. Electronic address:
Acer truncatum is a multifunctional tree species with broad applications in ornamental, healthy drink, and seed oil. In the present study, proanthocyanidins were isolated from the seed coats of A. truncatum, which were largely discarded as industrial wastes in seed oil production.
View Article and Find Full Text PDFSericin Protein: Structure, Properties, and Applications.
J Funct Biomater
October 2024
Department of Electronics, Information, and Bioengineering, Politecnico di Milano, 20133 Milan, Italy.
Silk sericin, the glue protein binding fibroin fibers together, is present in the silkworms' cocoons. In recent years, sericin has gained attention for its wide range of properties and possible opportunities for various applications, as evidenced by the meta-analysis conducted in this review. Sericin extraction methods have evolved over the years to become more efficient and environmentally friendly, preserving its structure.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!