AI Article Synopsis
- Recent focus has shifted to how polyphenols, an epigenetic-modulating diet, influence age-related progression and longevity at a molecular level.
- Natural compounds can enhance cellular longevity by modifying histones and increasing autophagy, which lowers acetyl coenzyme A (AcCoA) levels.
- Additionally, caloric restriction (CR) plays a crucial role in combatting cancer-related inflammation as it increases SIRT1 protein levels, promoting autophagy and potentially aiding in cancer prevention.
Article Abstract
In recent years, there has been a great deal of attention toward the molecular machinery relevant to age-related progression controlled through the external intervention of polyphenols- an epigenetic-modulating diet. Natural products modulate cellular longevity through histone post-translational modification and can also induce the upregulation of autophagy, thus reducing the level of acetyl coenzyme A (AcCoA). In addition, the effect of caloric restriction (CR) on cancer-related chronic inflammation is of great significance in aging. In line with this, SIRT1 protein levels are expanded in response to calorie restriction mimetics (CRM), in this way acting as autophagy inducers relevant to cancer prevention.
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| http://dx.doi.org/10.1016/j.biotechadv.2018.03.012 | DOI Listing |
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