Background And Objective: Recreational use of salvia divinorum (salvia), a potent, naturally occurring hallucinogen, is on the rise internationally. Despite the paucity of information about its long-term health effects, salvia is readily available and generally portrayed as a safe non-addictive substance.
Methods And Results: We report on two patients who presented with an enduring and pervasive pattern of salvia use.
Discussion And Conclusions: Evaluating patients for salvia use during clinical assessment is strongly encouraged, especially among young polysubstance users.
Scientific Significance: Clinicians should be mindful of the multifaceted psychiatric effects of salvia, including the potential for a use disorder. (Am J Addict 2018;27:163-165).
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http://dx.doi.org/10.1111/ajad.12715 | DOI Listing |
Pharmaceuticals (Basel)
November 2024
Departamento de Farmacia, Facultad de Química, Universidad Nacional Autónoma de México, Ciudad Universitaria, Coyoacán, Ciudad de Mexico 04510, Mexico.
Trigeminal neuralgia (TN) is chronic pain caused by damage to the somatosensorial system on the trigeminal nerve or its branches, which involves peripheral and central dysfunction pain pathways. Trigeminal pain triggers disruptive pain in regions of the face, including within and around the mouth. Besides clinical experiences, translating the language of suffering into scientific terminology presents substantial challenges.
View Article and Find Full Text PDFNan Fang Yi Ke Da Xue Xue Bao
November 2024
Department of Medicine, Hubei Enshi College, Enshi 445000, China.
Objective: To investigate the protective effect of total flavonoids of extract against acetaminophen (APAP) -induced acute liver injury (ALI) and its molecular mechanism.
Methods: The main chemical constituents of total flavonoids of were obtained through literature search, and their pharmacological mechanisms were predicted using bioinformatics analysis. In a mouse model of APAP-induced ALI, the protective effects of 100, 200 and 400 mg/kg total flavonoids of and 150 mg/kg bifidus were evaluated by observing changes in blood biochemistry and liver histopathology and detecting expressions of the key proteins in the Nrf2/HO-1 signaling pathway.
Physiol Plant
October 2024
Department of Biological Sciences, University of Calgary, 2500 University Dr. NW, Calgary, Alberta, Canada.
BMC Plant Biol
October 2024
Department of Cell and Systems Biology, University of Toronto, Toronto, ON, M5S 3G5, Canada.
Background: Diviner's sage (Salvia divinorum; Lamiaceae) is the source of the powerful hallucinogen salvinorin A (SalA). This neoclerodane diterpenoid is an agonist of the human Κ-opioid receptor with potential medical applications in the treatment of chronic pain, addiction, and post-traumatic stress disorder. Only two steps of the approximately twelve step biosynthetic sequence leading to SalA have been resolved to date.
View Article and Find Full Text PDFJ Ethnopharmacol
December 2024
Jiangsu Province Key Laboratory of Anesthesiology, Jiangsu Province Key Laboratory of Anesthesia and Analgesia Application Technology, NMPA Key Laboratory for Research and Evaluation of Narcotic and Psychotropic Drugs, School of Anesthesiology, Xuzhou Medical University, Xuzhou, 221004, China. Electronic address:
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