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| http://dx.doi.org/10.1371/journal.pgen.1007215 | DOI Listing |
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Unraveling the Mysteries of Sleep: Exploring Phylogenomic Sleep Signals in the Recently Characterized Archaeal Phylum Lokiarchaeota near Loki's Castle.
Int J Mol Sci
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Department of Pharmacology, JSS College of Pharmacy, JSS Academy of Higher Education & Research, Mysuru 570015, Karnataka, India.
Sleep is a universally conserved behavior whose origin and evolutionary purpose are uncertain. Using phylogenomics, this article investigates the evolutionary foundations of sleep from a never before used perspective. More specifically, it identifies orthologs of human sleep-related genes in the Lokiarchaeota of the Asgard superphylum and examines their functional role.
View Article and Find Full Text PDFThe Asgard archaeal ESCRT-III system forms helical filaments and remodels eukaryotic-like membranes.
EMBO J
January 2025
Department of Life Sciences, Ben-Gurion University of the Negev, Beer Sheva, 84105, Israel.
The ESCRT machinery mediates membrane remodeling in numerous processes in cells including cell division and nuclear membrane reformation. The identification of ESCRT homologs in Asgard archaea, currently considered the closest prokaryotic relative of eukaryotes, implies a role for ESCRTs in the membrane remodeling processes that occurred during eukaryogenesis. Yet, the function of these distant ESCRT homologs is mostly unresolved.
View Article and Find Full Text PDFStructures of Saccharolobus solfataricus initiation complexes with leaderless mRNAs highlight archaeal features and eukaryotic proximity.
Nat Commun
January 2025
Laboratoire de Biologie Structurale de la Cellule (BIOC), CNRS, Ecole polytechnique, Institut Polytechnique de Paris, Palaiseau, 91120, France.
The archaeal ribosome is of the eukaryotic type. TACK and Asgard superphyla, the closest relatives of eukaryotes, have ribosomes containing eukaryotic ribosomal proteins not found in other archaea, eS25, eS26 and eS30. Here, we investigate the case of Saccharolobus solfataricus, a TACK crenarchaeon, using mainly leaderless mRNAs.
View Article and Find Full Text PDFEngineering history with Asgard archaea of the kingdom Promethearchaeati.
Nat Microbiol
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Institute for Extra-Cutting-Edge Science and Technology Avant-Garde Research (X-star), Japan Agency for Marine-Earth Science and Technology (JAMSTEC), Kanagawa, Japan.
Complete genomes of Asgard archaea reveal diverse integrated and mobile genetic elements.
Genome Res
October 2024
Innovative Genomics Institute, University of California, Berkeley, California 94720, USA;
Article Synopsis
- Asgard archaea, key ancestors of Eukaryotes, have mobile genetic elements (MGEs) that are not well understood, and this study investigates two complete genomes from the Atabeyarchaeia lineage to explore these elements.
- The research identifies 18 MGEs in Atabeyarchaeia, including a notable 20.67 kbp circular plasmid and specific viruses that might influence their evolution through gene interactions.
- Differences in defense mechanisms, such as restriction-modification systems, between Atabeyarchaeia and another Asgard archaea, Freyarchaeia, highlight how these systems can affect the relationship with MGEs and contribute to genetic diversity in these organisms.*
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