SYSTEMS-2 is a randomised study of radiotherapy dose escalation for pain control in 112 patients with malignant pleural mesothelioma (MPM). Standard palliative (20 Gy/5#) or dose escalated treatment (36 Gy/6#) will be delivered using advanced radiotherapy techniques and pain responses will be compared at week 5. Data will guide optimal palliative radiotherapy in MPM.
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http://dx.doi.org/10.1016/j.ctro.2017.11.004 | DOI Listing |
Eur J Orthod
December 2024
Department of Prosthodontics and Orthodontics, Dental Institute, Faculty of Medicine, Jagiellonian University Medical College, Montelupich St. 4/108, 31-155 Krakow, Poland.
Background: The fear of pain during the various stages of orthodontic treatment with fixed appliances is a common concern of patients. Therefore, the present research aimed to thoroughly investigate the impact of bracket architecture on pain perception during active treatment, debonding, and adhesive removal.
Materials: One hundred consecutive patients who completed treatment with one of two bracket systems (2-slot brackets with an integral base or conventional twin brackets with foil mesh) were included in this prospective cohort study.
Contemp Clin Trials
June 2024
Johns Hopkins, School of Nursing, Baltimore, MD, USA.
Background: Few clinical trials include a detailed protocol for stakeholder engagement in the design and execution of the clinical trial. Deliver-EE is a pragmatic clinical trial to assess how different types of home-delivered meals can affect older adults' health and well-being. We present the protocol for stakeholder engagement in this national, multi-site trial and initial findings from our efforts.
View Article and Find Full Text PDFCureus
November 2023
Internal Medicine, Cardiology, McKinney Family Medicine, McKinney, USA.
Stroke
June 2023
Charité Lab for Artificial Intelligence in Medicine (CLAIM) (E.M.Z.A., A.H., D.F.), Charité Universitätsmedizin Berlin, Germany.
Background: Established randomized trial-based parameters for acute ischemic stroke group patients into generic treatment groups, leading to attempts using various artificial intelligence (AI) methods to directly correlate patient characteristics to outcomes and thereby provide decision support to stroke clinicians. We review AI-based clinical decision support systems in the development stage, specifically regarding methodological robustness and constraints for clinical implementation.
Methods: Our systematic review included full-text English language publications proposing a clinical decision support system using AI techniques for direct decision support in acute ischemic stroke cases in adult patients.
Orphanet J Rare Dis
March 2023
National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Background: Direct estimates of rare disease prevalence from public health surveillance may only be available in a few catchment areas. Understanding variation among observed prevalence can inform estimates of prevalence in other locations. The Muscular Dystrophy Surveillance, Tracking, and Research Network (MD STARnet) conducts population-based surveillance of major muscular dystrophies in selected areas of the United States.
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