AI Article Synopsis
- The study looked at a specific gene related to a lack of oxygen in tumors to see how it affects head and neck cancer patients.
- Researchers analyzed tumor samples from 118 patients with oral cancer to find out how this gene's activity (mRNA level) influences survival and the chance of cancer coming back after treatment.
- Results showed that high levels of this gene are linked to worse survival rates and a higher risk of cancer returning, making it an important marker for doctors to consider.
Article Abstract
Background And Purpose: Hypoxia gene expression signatures are of high prognostic value for head and neck cancer patients. Recently, the prognostic information of a multiple-gene hypoxia signature was found to be provided by the mRNA level of alone (Tawk et al., 2016). Therefore, we studied the prognostic value of in an independent cohort of oral squamous cell carcinoma (OSCC) patients.
Material And Methods: Frozen tumor samples of 118 adult OSCC patients were analysed for mRNA level by quantitative real-time TaqMan™ PCR analysis. Kaplan-Meier analysis and Cox's regression analysis were performed to characterize the prognostic impact of mRNA level in OSCC patients.
Results: The analyzed patient cohort was divided into four subgroups according to the quartiles of the mRNA levels. The highest intratumoral mRNA level was significantly correlated with a poor overall survival (RR = 2.2; = 0.04) and an increased risk of locoregional recurrence (RR = 4.8; = 0.02). In patients who received radiotherapy ( = 82) highest intratumoral mRNA level was significantly correlated with a poor overall survival (RR = 3.4; = 0.01) and an increased risk of locoregional recurrence (RR = 10.3; = 0.005). Moreover, significant correlations between the mRNA level and the mRNA level of several EMT and stem cell markers were found.
Conclusions: A high mRNA level, as a single-gene surrogate of hypoxia, is an independent prognostic marker for the overall survival and locoregional recurrence of OSCC patients.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5833914 | PMC |
| http://dx.doi.org/10.1016/j.ctro.2017.05.002 | DOI Listing |
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