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Effect of a novel leukotriene D4 antagonist with 5-lipoxygenase and cyclooxygenase inhibitory activity, Wy-45,911, on leukotriene-D4-and antigen-induced bronchoconstriction in the guinea pig.
Int Arch Allergy Appl Immunol
June 1988
Wyeth Laboratories, Inc., Philadelphia, Pa.
Wy-45,911 (4-[hydroxy-[3-(2-quinolinylmethoxy)phenyl] amino]-4-oxabutanoic acid, methyl ester) was found to inhibit competitively leukotriene D4 (LTD4)-induced contractions of the isolated guinea pig trachea but not those of leukotriene C4 (LTC4), even in the presence of a gamma-glutamyltranspeptidase inhibitor, reduced glutathione (GSH). Tracheal contractions induced by histamine or pilocarpine were also not significantly altered by Wy-45,911. The drug inhibited the tracheal contractions induced by antigen, even in the presence of GSH.
View Article and Find Full Text PDFWy-45,911: a novel leukotriene antagonist with lipoxygenase inhibitory activity.
Adv Prostaglandin Thromboxane Leukot Res
November 1987
Wyeth Laboratories, Inc., Philadelphia, Pennsylvania 19101.
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