is a leading cause of dysentery worldwide, responsible for up to 165 million cases of shigellosis each year. is also recognised as an exceptional model pathogen to study key issues in cell biology and innate immunity. Several infection models have been useful to explore biology; however, we still lack information regarding the events taking place during the infection process Here, we discuss a selection of mechanistic insights recently gained from studying infection of zebrafish (), with a focus on cytoskeleton rearrangements and cellular immunity. We also discuss how infection of zebrafish can be used to investigate new concepts underlying infection control, including emergency granulopoiesis and the use of predatory bacteria to combat antimicrobial resistance. Collectively, these insights illustrate how infection of zebrafish can provide fundamental advances in our understanding of bacterial pathogenesis and vertebrate host defence. This information should also provide vital clues for the discovery of new therapeutic strategies against infectious disease in humans.
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| http://dx.doi.org/10.1242/dmm.032151 | DOI Listing |
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