The antibacterial-guided investigation of the stem bark extract of Pseudocedrela kotschyi led to the isolation of a new secotirucallane triterpene derivative: 4-hydroxy-3,4-secotirucalla-7,24-dien-3,21-dioic acid (1), together with the known one: 3,4-secotirucalla-4(28),7,24-trien-3,21-dioic acid (2) and 3-methyl ester 3,4-secotirucalla-4(28),7,24-trien-3,21-dioic (3). The structures of the isolated compounds were elucidated on the basis of extensive 1D- and 2D-NMR spectroscopy. Extracts, fractions and compounds (1-3) were tested in vitro for antibacterial activity against two Gram positive bacteria (Bacillus subtilis and Staphylococcus aureus ATCC 25923), and two Gram negative bacteria (Escherichia coli S2(1) and Pseudomonas aeruginosa). The MeOH extract and the Hex/CH2Cl2 (70:30) fraction showed significant levels of activity (MIC=64- 256 μg/mL) compared with the two reference drugs [ciprofloxacin: MIC (0.5-1 μg/mL) and amoxicillin: MIC (1-128 μg/mL)]. Moreover, the compound 2 isolated from this Hex/CH2Cl2 (70:30) fraction had the greatest potential value against S. aureus, E. coli and P. aeruginosa, with minimum inhibitory concentrations (MIC) ranging from 4-16 μg/mL.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1515/znc-2017-0207 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Flight phenology and influence of region and habitat on the abundance of Xylosandrus germanus and Anisandrus maiche (Coleoptera: Curculionidae: Scolytinae) in New York.
Environ Entomol
January 2025
Cornell Cooperative Extension - Lake Ontario Fruit Program, Albion, NY, USA.
The non-native wood-boring and symbiotic fungus-culturing Xylosandrus germanus (Blandford) was first reported in New York apple orchards in 2013. Trapping surveys have been conducted annually since to assist growers in timely applications of preventative control measures. In 2021, a similar-looking introduced species, Anisandrus maiche (Kurentsov), was identified in traps in west central New York.
View Article and Find Full Text PDFIn Situ Analysis of Plant Tissue Using Arc iKnife Ionization Mass Spectrometry.
Anal Chem
January 2025
Cigar Technology Innovation Center of China Tobacco, Cigar Fermentation Technology Key Laboratory of China Tobacco (China Tobacco Sichuan Industrial Co., Ltd.), Chengdu 610066, People's Republic of China.
This study developed a portable arc iKnife ionization mass spectrometry (AII-MS) technique integrating a surgical knife with low-temperature arc plasma to interact with plant tissues. The thermal energy from the arc plasma induces the sputtering of water-containing plant tissues, leading to the formation of aerosols. These aerosols are then charged by plasma-generated ions, producing charged microdroplets that are ultimately detected by a mass spectrometer.
View Article and Find Full Text PDFNew Evidence for Scop. Extracts Application in Gastrointestinal Ailments.
Pharmaceuticals (Basel)
January 2025
Institute for Medicinal Plants Research "Dr. Josif Pančić", Tadeuša Košćuška 1, 11000 Belgrade, Serbia.
Background/objectives: Scop. is traditionally used for treatment of various gastrointestinal ailments. In this study, we investigated the phytochemical profile and biological activities of leaves, bark and flowers extracts of Methods: Phytochemical analysis was performed using HPLC.
View Article and Find Full Text PDFCrude Drugs for Clearing Heat Contain Compounds Exhibiting Anti-Inflammatory Effects in Interleukin-1β-Treated Rat Hepatocytes.
Molecules
January 2025
Department of Medical Biosciences, Faculty of Life Sciences, Ritsumeikan University, Kusatsu 525-8577, Shiga, Japan.
Traditional Japanese medicines, i.e., Kampo medicines, consist of crude drugs (mostly plants) that have empirical pharmacological functions ('' in Japanese), such as clearing heat.
View Article and Find Full Text PDFTropical tree species with high wood specific gravity have higher concentrations of wood phosphorus and are more efficient at resorbing it.
AoB Plants
January 2025
CNRS, UMR Ecologie des Forêt de Guyane (EcoFoG), AgroParisTech, CIRAD, INRAE, Université des Antilles, Université de Guyane, 97310 Kourou, France.
Phosphorus (P) and potassium (K) play important roles in plant metabolism and hydraulic balance, respectively, while calcium (Ca) and magnesium (Mg) are important components of cell walls. Although significant amounts of these nutrients are found in wood, relatively little is known on how the wood concentrations of these nutrients are related to other wood traits, or on the factors driving the resorption of these nutrients within stems. We measured wood nutrient (i.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!