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Identification and phylogenetic analysis of Jingmen tick virus in ticks and sheep from Henan Province, China.
Virol J
December 2024
Shandong Second Medical University, Weifang, 261053, China.
Jingmen tick virus (JMTV) is a novel segmented Flavivirus that was first identified from Rhipicephalus microplus in the Jingmen region of Hubei Province, China, in 2010. Subsequently, it was detected in a variety of countries and regions around the world. Meanwhile, JMTV has been proved to be pathogenic to humans and animals and could cause viremia in animals.
View Article and Find Full Text PDFImmunomodulatory features of MSC-derived exosomes decorated with DC-specific aptamer for improving sublingual immunotherapy in allergic mouse model.
Stem Cell Res Ther
December 2024
Cellular and Molecular Research Center, Medical Basic Sciences Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Introduction: Sublingual immunotherapy (SLIT) is an effective and injection-free route for allergen-specific immunotherapy (AIT). Mesenchymal stromal/stem cell (MSC)-derived exosomes (Exo) has been identified as a novel delivery platform with immunomodulatory capacities. In addition, targeting agents such as aptamers (Apt) have been extensively used for specific delivery approaches such as direct delivery of allergen formulations to dendritic cells (DC) to improve the efficacy of specific immunotherapy.
View Article and Find Full Text PDFTransport-related respiratory pathogens in horses travelling long distances: A prospective study on arrival at the slaughterhouse.
Res Vet Sci
December 2024
Department of Veterinary Medicine, University of Bari, 70010 Valenzano, Bari, Italy.
Respiratory disorders (RDs) are a common transport-related welfare consequence in horses. This prospective study described the journeys of horses transported to two slaughterhouses in Italy, documented the prevalence of potentially RD-related pathogens, and identified possible predisposing factors. Data were recorded from arrival until 48 h after arrival and included the collection of Deep Nasopharyngeal Swabs (DNS), journey details and welfare assessment of horses (n = 155).
View Article and Find Full Text PDFWide spectrum of tick-borne pathogens in juvenile Ixodes ricinus collected from autumn-migrating birds in the Vistula River Valley, Poland.
BMC Vet Res
December 2024
Anses, INRAE, Ecole Nationale Vétérinaire d'Alfort, UMR BIPAR, Laboratoire de Santé Animale, Maisons-Alfort, 94700, France.
Background: Migratory birds serve as potential hosts for ticks and can be reservoirs of tick-borne pathogens (TBPs). The aim of our study was to investigate the prevalence of TBPs in juvenile Ixodes ricinus collected from Erithacus rubecula, Turdus merula, and Turdus philomelos passing through the Vistula River Valley, Poland - one of the most important European north-south routes for migratory birds.
Methods: To detect TBPs in collected ticks we used a high-throughput microfluidic real-time PCR method.
An ACE2 PET imaging agent derived from F/Cl exchange of MLN-4760 under phase transfer catalysis.
EJNMMI Radiopharm Chem
December 2024
Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai, 201800, China.
Background: Angiotensin-converting enzyme-2 (ACE2) acts as a key regulatory molecule and important therapeutic target in the pathological remodeling of numerous organs and diseases. In this study, a rapid, simple, and efficient synthetic route with a catalytic, F-for-Cl (F/Cl) exchange scheme was designed for the preparation of F-labeled MLN-4760, and its targeting ability was investigated in a humanized ACE2 mouse model.
Results: A novel F-labeled MLN-4760 radioligand, abbreviated as F-MLN-4760, was successfully synthesized by the F/Cl exchange-labeling, and was purified by SepPak C18 columns with a radiochemical yield of 30% and a radiochemical purity of 29.
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