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Microsensor systems for cell metabolism - from 2D culture to organ-on-chip (2019-2024).
Lab Chip
January 2025
Laboratory for Electrical Instrumentation and Embedded Systems, IMTEK - Department of Microsystems Engineering, University of Freiburg, Georges-Köhler-Allee 103, 79110 Freiburg, Germany.
Cell cultures, organs-on-chip and microphysiological systems become increasingly relevant as models, , in drug development, disease modelling, toxicology or cancer research. It has been underlined repeatedly that culture conditions and metabolic cues have a strong or even essential influence on the reproducibility and validity of such experiments but are often not appropriately measured or controlled. Here we review microsensor systems for cell metabolism for the continuous measurement of culture conditions in microfluidic and lab-on-chip platforms.
View Article and Find Full Text PDFGuyton's hemodynamic mosaic: crafting fluid management with precision.
Ann Intensive Care
January 2025
Intensive Care Department, Hospital Israelita Albert Einstein, Av. Albert Einstein, 627/701 - Morumbi, São Paulo, CEP: 05651-901, SP, Brasil.
Sheldon Magder's article on applying Arthur Guyton's principles to clinical fluid management provides valuable insights into optimizing hemodynamics in critically ill patients. While emphasizing the role of right atrial pressure (RAP) in assessing cardiac output, challenges arise due to RAP's variable accuracy and the oversimplification of cardiovascular dynamics. Integrating RAP with dynamic assessments and bedside ultrasound can enhance fluid management strategies.
View Article and Find Full Text PDFConcise Recommendations for EDitorials: Enhancing Narratives and Composition Effectively (CREDENCE).
J Korean Med Sci
December 2024
Division of Musculoskeletal and Dermatological Sciences, Centre for Musculoskeletal Research, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK.
An editorial article is a type of scholarly communication providing expert views and critical analysis of issues. It may reflect the view of the author(s) or of the organization/journal on a certain topic. An editorial may also comment on a published paper.
View Article and Find Full Text PDFAnisogamy and sex roles: a commentary.
Evol Lett
December 2024
Department of Life Sciences, Milner Centre for Evolution, University of Bath, Bath BA2 7AY, United Kingdom.
The origin and maintenance of sex differences in reproductive behavior (often labeled sex roles) have remained controversial topics, and recent meta-analyses and theoretical models have helped to elucidate the processes that generate diverse sex roles. We are glad to see that our study (Mokos et al., 2021) generated a healthy debate, and in agreement with recent commentaries (Janicke, 2024; Lehtonen & Parker, 2024) we call for a more comprehensive approach to understanding sex role evolution.
View Article and Find Full Text PDFPhotothermal spectroscopy on-chip sensor for the measurement of a PMMA film using a silicon nitride micro-ring resonator and an external cavity quantum cascade laser.
Nanophotonics
May 2024
Centre for Advanced Photonics and Process Analysis, Munster Technological University, T12 T66T Bishopstown, Cork, Ireland.
Article Synopsis
- - Laser-based mid-IR photothermal spectroscopy (PTS) is a rapid and sensitive analytical method that utilizes advanced laser technology to capture the absorption characteristics of various materials, such as liquids or solids.
- - This study utilizes an external cavity quantum cascade laser (EC-QCL) to analyze a thin film of polymethyl methacrylate (PMMA) on a silicon nitride micro-ring resonator, demonstrating its effectiveness in creating an on-chip photothermal sensor.
- - The research highlights the optimal alignment and focusing techniques for the laser setup, showing that PTS can lead to compact, efficient sensors suitable for real-time monitoring in industrial applications.
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