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Liver and Statins: A Critical Appraisal of the Evidence. | LitMetric

Liver and Statins: A Critical Appraisal of the Evidence.

Curr Med Chem

Sezione di Medicina Interna e Malattie Metaboliche, Dipartimento di Medicina Interna e Specialistica, DIBIMIS, Universita di Palermo, Palermo, Italy.

Published: March 2019

AI Article Synopsis

  • * Genetic factors can impact how individuals react to statins, making the study of specific genes important for understanding susceptibility to these adverse events.
  • * This review also evaluates the effectiveness and safety of statins in treating cardiovascular diseases, particularly for patients with metabolic syndrome and HCV infections.

Article Abstract

Adverse drug reactions (ADRs) represent an important cause of morbidity and mortality worldwide. Statins are a class of drugs whose main adverse effects are drug-induced liver injury (DILI) and myopathy. Some of these may be predictable, due to their pharmacokinetic and pharmacodynamic properties, while others, unfortunately, are idiosyncratic. Genetic factors may also influence patient susceptibility to DILI and myopathy in the case of statins. This review will first discuss the role of statins in cardiovascular disease treatment and prevention and the underlying mechanisms of action. Furthermore, to explore the susceptibility of statin-induced adverse events such as myopathy and hepatotoxicity, it will then focus on the recent Genome-Wide Association Studies (GWAS) concerning the transporter genes, Cytochrome P450 (CYP), organic anion-transporting polypeptide (OATP) and ABCB1 and ABCC1, which seem to play a role in the development of clinically relevant adverse events. Finally, we appraise the evidence for and against the use of statins in metabolic syndrome and in HCV-infected patients, in terms of their safety and efficacy in cardiovascular events.

Download full-text PDF

Source
http://dx.doi.org/10.2174/0929867325666180327095441DOI Listing

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