AI Article Synopsis
- D-dimer tests, along with clinical pre-test probability scores, help assess the risk of venous thromboembolic events (VTE), but d-dimer levels can naturally rise with age.
- A recent review found that using an age-adjusted D-dimer for patients over 50 improves specificity without sacrificing sensitivity in low-risk VTE cases.
- This study analyzed patients who had ultrasound Doppler tests from 2011 to 2014, comparing the effectiveness of age-adjusted D-dimer levels against traditional cut-off values.
Article Abstract
D-dimers combined with clinical pre-test probability (PTP) scores are used to determine the likelihood of a venous thromboembolic event (VTE). It is recognised that with advancing age, d-dimer values increase, leading to a cohort of patients with a d-dimer above the standard cut-off of 500g/L. A recent systemic review, examined the accuracy of an age-adjusted D-dimer in those aged > 50 years with a low clinical risk of a VTE. This showed an increase in specificity without loss of sensitivity. Our study, aimed to examine a population of patients, who between 2011 and 2014 underwent ultrasound Doppler studies of lower limbs. By applying a corresponding age-adjusted D-dimer, we determined the sensitivity and specificity and compared this to use of conventional D-dimer.
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