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Relationship between Response to PDE5 Inhibitors and Penile Duplex Doppler Ultrasound in Erectile Dysfunction. | LitMetric

Relationship between Response to PDE5 Inhibitors and Penile Duplex Doppler Ultrasound in Erectile Dysfunction.

Med Sci (Basel)

Department of Urology, Giresun University Faculty of Medicine, Giresun, Sağlık Uygulama ve Araştırma Hastanesi Nizamiye Mah. Mumcular Sok. No: 1/1, 1 nolu Sağlık Ocağı Arkası, Merkez, Giresun P.K. 28200, Turkey.

Published: March 2018

AI Article Synopsis

  • * Factors like diabetes mellitus and dyslipidemia negatively impacted treatment responses, while conditions such as hypertension, Peyronie's disease, and priapism were linked to better responses.
  • * The results indicated that patients without arterial or venous insufficiency had the highest treatment success rates, highlighting that specific vascular conditions can influence the effectiveness of therapy.

Article Abstract

The relationship between the results of penile duplex Doppler ultrasound (PDDU) and response to vardenafil was investigated in patients diagnosed with erectile dysfunction (ED). Data from 148 patients with ED were analyzed retrospectively. Patients who did not respond to therapy were classified in to Group I ( = 32), those who responded partially were classified into Group II ( = 40), and complete responders were classified into Group III ( = 76). Age, comorbidities, and vascular and penile pathologies were compared among the three groups. While diabetes mellitus (DM) and dyslipidemia positivity adversely affected the response to treatment, the presence of hypertension (HT), Peyronie's disease and priapism increased the therapeutic response to the treatment ( < 0.05). Arterial insufficiency was present in 20 (30.3%), 25 (37.9%) and 21 (31.8%) of the patients in Group I, Group II and Group III, respectively ( 0.001). Venous insufficiency was observed in three (14.3%) patients in Group I and in eight (85.7%) patients in Group III ( 0.001). Arterial/venous insufficiency was seen in 9 (30%), 14 (46.7%) and 7 (23.3%) of the patients in Group I, Group II and Group III, respectively ( 0.001). The response rate to treatment was highest in normal patients according to PDDU, followed by patients with venous insufficiency. In addition, it was found that DM decreased the response to treatment, whereas the response increased in cases with HT, priapism and Peyronie's disease.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6024826PMC
http://dx.doi.org/10.3390/medsci6020028DOI Listing

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