A 60-year-old man with a past history of sprue was admitted with cough and dyspnea and was found to have diffuse, bilateral interstitial lung disease with Kerley-B lines and pleural effusions. An open lung biopsy revealed a diffuse lymphatic infiltration of the interstitium with lymphocytes which were judged to be neoplastic rather than inflammatory. Thus non-Hodgkin's lymphoma was diagnosed. A good response to therapy was obtained.
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