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Advancing allergic rhinitis research through phenome-wide association studies: Insights from known genetic loci.
World Allergy Organ J
January 2025
Institute of Life Science, Chongqing Medical University, Chongqing, China.
Background: Allergic rhinitis (AR) is a common chronic respiratory disease that can lead to the development of various other conditions. Although genetic risk loci associated with AR have been reported, the connections between these loci and AR comorbidities or other diseases remain unclear.
Methods: This study conducted a phenome-wide association study (PheWAS) using known AR risk loci to explore the impact of known AR risk variants on a broad spectrum of phenotypes.
The multi-dimensional stigma of chronic pain: A narrative review.
Curr Opin Psychol
December 2024
Doctorate in Clinical Psychology, Department of Psychology, Royal Holloway, University of London, United Kingdom; Nuffield Department of Orthopaedics, Rheumatology, and Musculoskeletal Sciences (NDORMS), University of Oxford, United Kingdom.
Accumulating evidence suggests that stigma is a pervasive and pernicious psychosocial phenomenon that affects people living with chronic pain. In this narrative review, we describe the nature of stigma experienced by people with chronic pain and discuss its multifaceted determinants. These determinants include features of pain itself and intersectional factors, including comorbid conditions and social marginalization.
View Article and Find Full Text PDFAutoimmune diseases and risk of gastrointestinal cancer: an umbrella review of meta-analyses of observational studies.
Int J Surg
January 2025
Department of Surgical Oncology, Fourth Affiliated Hospital of China Medical University.
Background: Several autoimmune diseases (ADs) are considered risk factors for gastrointestinal (GI) cancers. This study pooled and appraised the evidence associating ADs to GI cancer risks.
Methods: Three databases were examined from initiation through 26 January 2024.
Knowledge, Attitudes, and Practices of Primary School Teachers Regarding Deleterious Oral Habits Leading to Malocclusion in School Children: A Cross-Sectional Study.
Cureus
December 2024
Conservative Dentistry and Endodontics, Narayana Dental College and Hospital, Nellore, IND.
Background Oral habits are most initiated at the primary school age. Primary school children are seen to have been performing these habits during their active school hours. The peak days they are in school are the most active hours during which the tendency to perform this habit occurs.
View Article and Find Full Text PDFNon-spike protein inhibition of SARS-CoV-2 by natural products through the key mediator protein ORF8.
Mol Biol Res Commun
January 2025
Faculty of Life Sciences and Biotechnology, Shahid Beheshti University, Tehran, Iran.
The recent pernicious COVID-19 pandemic is caused by SARS-CoV-2. While most therapeutic strategies have focused on the viral spike protein, Open Reading Frame 8 (ORF8) plays a critical role in causing the severity of the disease. Nonetheless, there still needs to be more information on the ORF8 binding epitopes and their appropriate safe inhibitors.
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