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[Metabolic engineering of for thymidine production].
Sheng Wu Gong Cheng Xue Bao
August 2024
School of Biological Engineering, Tianjin University of Science and Technology, Tianjin 300457, China.
Thymidine, as a crucial precursor of anti-AIDS drugs (e.g., zidovudine and stavudine), has wide application potential in the pharmaceutical industry.
View Article and Find Full Text PDFGiardia intestinalis thymidine kinase is a high-affinity enzyme crucial for DNA synthesis and an exploitable target for drug discovery.
J Biol Chem
June 2022
Department of Medical Biochemistry and Biophysics, Umeå University, Umeå, Sweden. Electronic address:
Giardiasis is a diarrheal disease caused by the unicellular parasite Giardia intestinalis, for which metronidazole is the main treatment option. The parasite is dependent on exogenous deoxyribonucleosides for DNA replication and thus is also potentially vulnerable to deoxyribonucleoside analogs. Here, we characterized the G.
View Article and Find Full Text PDFAdult T-Cell Leukemia: a Comprehensive Overview on Current and Promising Treatment Modalities.
Curr Oncol Rep
November 2021
Department of Experimental Pathology, Immunology and Microbiology, Faculty of Medicine, American University of Beirut, Beirut, Lebanon.
Article Synopsis
- Adult T-cell leukemia (ATL) is a severe cancer linked to the HTLV-1 virus, with limited effective treatment options and poor prognosis.
- Current treatments, such as antiviral therapies and monoclonal antibodies, show some responses but often fail to improve overall survival rates for patients.
- Developing targeted therapies that focus on the HTLV-1 proteins and boosting the host's immune response presents a hopeful avenue for better treatment outcomes in ATL.
Surmounting Cytarabine-resistance in acute myeloblastic leukemia cells and specimens with a synergistic combination of hydroxyurea and azidothymidine.
Cell Death Dis
May 2019
The Fred Wyszkowski Cancer Research Laboratory, Department of Biology, Technion-Israel Institute of Technology, Haifa, Israel.
Acute myeloid leukemia (AML) patients display dismal prognosis due to high prevalence of refractory and relapsed disease resulting from chemoresistance. Treatment protocols, primarily based on the anchor drug Cytarabine, remained chiefly unchanged in the past 50 years with no standardized salvage regimens. Herein we aimed at exploring potential pre-clinical treatment strategies to surmount Cytarabine resistance in human AML cells.
View Article and Find Full Text PDFSuccessful prevention of perinatal HIV transmission utilizing direct observation therapy in the setting of Acquired Immunodeficiency Syndrome (AIDS) and progressive multifocal leukoencephalopathy.
IDCases
September 2018
Hahnemann University Hospital, Drexel University College of Medicine, Philadelphia, PA, United States.
We report a case of a 22-year-old G1P0010 African-American female with poorly controlled perinatally acquired HIV/AIDS and recent diagnosis of progressive multifocal leukoencephalopathy (PML) by magnetic resonance imaging (MRI). She presented to a tertiary care facility for prenatal care and direct observation therapy after poor medication adherence during pregnancy. After multiple attempts at outpatient ART management, the patient was admitted at 35 weeks' gestation for direct observation therapy for both antiretroviral therapy and anti-seizure medication.
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