A PHP Error was encountered

Severity: Warning

Message: file_get_contents(https://...@pubfacts.com&api_key=b8daa3ad693db53b1410957c26c9a51b4908&a=1): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests

Filename: helpers/my_audit_helper.php

Line Number: 176

Backtrace:

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 176
Function: file_get_contents

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 250
Function: simplexml_load_file_from_url

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 1034
Function: getPubMedXML

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 3152
Function: GetPubMedArticleOutput_2016

File: /var/www/html/application/controllers/Detail.php
Line: 575
Function: pubMedSearch_Global

File: /var/www/html/application/controllers/Detail.php
Line: 489
Function: pubMedGetRelatedKeyword

File: /var/www/html/index.php
Line: 316
Function: require_once

Effect of hydrochlorothiazide on serum uric acid concentration: a genome-wide association study. | LitMetric
Browse Categories

Effect of hydrochlorothiazide on serum uric acid concentration: a genome-wide association study.

Eero M Ala-Mutka Jenni M Rimpelä Frej Fyhrquist Kimmo K Kontula Timo P Hiltunen

Pharmacogenomics

Department of Medicine, University of Helsinki, Helsinki, Finland.

Published: April 2018

Aim: To recognize genetic associations of hydrochlorothiazide-induced change in serum uric acid (SUA) concentration.

Patients & Methods: We conducted a genome-wide association study on hydrochlorothiazide-induced change in SUA in 214 Finnish men from the GENRES study. Replication analyses were performed in 465 Finns from the LIFE study.

Results: In GENRES, we identified 31 loci associated with hydrochlorothiazide-induced change in SUA at p < 5 × 10. rs1002976 near VEGFC associated with the change in GENRES and in LIFE. rs950569 near BRINP3 associated with the change in SUA in GENRES and LIFE. The analysis of previously reported SNPs and candidate genes provided some proof for PADI4 and ABCC4.

Conclusion: We report genetic markers that may predict the increase in SUA concentration during thiazide treatment.

Download full-text PDF

 Source
http://dx.doi.org/10.2217/pgs-2017-0184DOI Listing

Publication Analysis

Top Keywords

hydrochlorothiazide-induced change
12
serum uric
8
uric acid
8
genome-wide association
8
association study
8
change sua
8
hydrochlorothiazide serum
4
acid concentration
4
concentration genome-wide
4
study aim
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!

Privacy Policy Site Map

© LitMetric 2025. All rights reserved.