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D-Penicillamine-Induced Stevens-Johnson Syndrome in a Patient with Gold Cyanide Intoxication: A Case Report.
Clin Cosmet Investig Dermatol
October 2024
Division of Dermatology, Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
D-penicillamine is used as the mainstay of chelation therapy for Wilson's disease and for heavy metal intoxication. D-penicillamine itself has been noted to cause several systemic side effects as well as symptoms related to the skin. Common cutaneous side effects such as acute hypersensitivity reactions, elastic fiber abnormalities, and bullous diseases have been occasionally described.
View Article and Find Full Text PDFBullous pemphigoid induced by penicillamine in a patient with Wilson disease.
Am J Clin Dermatol
May 2009
Department of Dermatology and Venereology, School of Medicine, University of Belgrade, Belgrade, Serbia.
We report a 47-year-old man with Wilson disease who developed bullous lesions on the trunk and extremities after 20 years of penicillamine treatment. The histologic and immunofluorescence findings were diagnostic of bullous pemphigoid. When penicillamine was replaced by zinc sulfate, the patient's bullous skin lesions improved rapidly.
View Article and Find Full Text PDFBullous lesions in scleroderma.
Int J Dermatol
June 2002
Department of Dermatology, of Johns Hopkins University, School of Medicine, Baltimore, MD, USA.
Background: The occurrence of bullous lesions in localized or systemic scleroderma is rare. Three histologic patterns have been reported: lichen sclerosus et atrophicus-like, lymphangiectatic blisters and autoimmune blistering diseases.
Objective: To investigate the frequency, clinical, and immunopathologic features of patients with scleroderma and bullous eruptions and to review the literature regarding this rare condition.
[D-penicillamine-induced pemphigus, polymyositis and myasthenia].
Ann Dermatol Venereol
February 1999
Service de Dermatologie, CHU Trousseau, Tours.
Background: D-penicillamine can induce autoimmune disease, particularly in patients with associated immune disorders.
Case Report: A 67-year old woman who had been taking D-penicillamine for 15 months for rheumatoid arthritis was hospitalized due to the development of a bullous eruption and proximal muscle deficiency. Search for intercellular antisubstance antibodies in serum was negative.
Penicillamine-induced degenerative dermatoses: report of a case and brief review of such dermatoses.
J Dermatol
July 1997
Department of Dermatology, Faculty of Medicine, University of Tokyo, Japan.
We describe a case of elastosis perforans serpiginosa with additional findings of degenerative skin changes. A 20-year-old man with hepatolenticular degeneration, under prolonged treatment with D-penicillamine, presented with a circular or serpiginous arrangement of nuchal papules. Histopathologically, transepidermal channels were accompanied by granulomatous reactions, with several giant cells engulfing elastic fibers.
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