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| http://dx.doi.org/10.4103/0366-6999.228250 | DOI Listing |
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Efficacy and Safety of Ciprofol for Anesthesia in Painless Colonoscopy with Varying Body Mass Indices Patients: A Prospective, Single-Center, Observational Study.
Drug Des Devel Ther
January 2025
Department of Anesthesiology, Jiangxi Provincial People's Hospital, The First Affiliated Hospital of Nanchang Medical College, Nanchang, Jiangxi, 330006, People's Republic of China.
Background: Ciprofol, a novel intravenous anesthetic derived from propofol, exhibits high lipophilicity. Its pharmacokinetics and pharmacodynamics may vary across different body mass indices (BMI) categories, but data on its optimal dosing as well as its safety and efficacy during colonoscopy anesthesia in varying BMI groups are lacking.
Objective: To evaluate the efficacy and safety of ciprofol during anesthesia for painless colonoscopy in patients with varying BMI, and to explore the correlation between BMI and induction dose.
Nursing Intervention Based on the Interactive Attainment Model.
Nurs Sci Q
January 2025
Gastrointestinal Surgery, Hangzhou First People's Hospital, Affiliated to Zhejiang University School of Medicine, Hangzhou City, Zhejiang Province, China.
This study aimed to examine the effectiveness of nursing that was based on the interactive attainment model in alleviating anxiety and pain during colonoscopy. This retrospective study included 213 patients, divided into intervention and control groups. Both groups underwent normal or painless colonoscopy.
View Article and Find Full Text PDFThe efficacy and safety of remimazolam in painless colonoscopy: a prospective, randomized clinical trial.
Front Med (Lausanne)
November 2024
Department of Pain Management, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China.
Article Synopsis
- Remimazolam is a new intravenous anesthetic that aims to provide effective sedation for colonoscopy with fewer cardiovascular and respiratory side effects compared to propofol.
- A clinical study involving 225 patients evaluated two doses of remimazolam against propofol, focusing on sedation success rates, safety, and recovery times.
- Results showed high sedation success (100%) for high-dose remimazolam and propofol, but lower (89%) for low-dose remimazolam, plus lower adverse effects in remimazolam groups compared to propofol.
Comparative Analysis of Hemodynamic Effects of Remimazolam and Propofol Combined with Esketamine in Colonoscopic Procedures in the Elderly.
Drug Des Devel Ther
November 2024
Department of Anesthesia, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, 121000, People's Republic of China.
Article Synopsis
- The study compares the effects of remimazolam combined with esketamine versus propofol combined with esketamine on the heart and blood pressure in elderly patients during painless colonoscopies.
- A total of 754 patients were equally divided into two groups, with results showing that those on the remimazolam-esketamine combo had significantly less hypotension and fewer heart rate issues compared to the propofol group.
- Overall, the remimazolam group demonstrated better hemodynamic stability, quicker recovery, and fewer side effects, all while achieving full sedation success.
The efficacy and safety of ciprofol versus propofol in patients undergoing painless hysteroscopy: a randomized, double-blind, controlled trial.
BMC Anesthesiol
November 2024
Department of Anesthesiology, the First Central Hospital of Baoding, No.443 Wusi East Road, Lianchi District, Baoding, 071000, P.R. China.
Article Synopsis
- Ciprofol has been shown to cause less injection pain compared to propofol in procedures like gastroscopy, but its effects during painless hysteroscopy were not fully understood until this study.
- A randomized controlled trial with 217 patients found that the injection pain rate was significantly lower in the ciprofol group (18.35%) compared to the propofol group (40.74%), while both groups had a 100% sedation success rate.
- Ciprofol also resulted in fewer adverse events, higher patient satisfaction scores, and more stable blood pressure measurements than propofol, indicating it may be a better option for anesthesia in painless procedures.
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