Transporters of the RND superfamily are well-known as the major drug efflux pumps of Gram-negative bacteria. However, they are widespread in organisms ranging from Archaea to Eukaryotes, and perform diverse functions. This review gives a brief overview of these diverse members of the superfamily with emphasis on their structure and functions.
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| http://dx.doi.org/10.1016/j.resmic.2018.03.001 | DOI Listing |
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Dystonia caused by ANO3 variants is due to attenuated Ca influx by ORAI1.
BMC Med
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Physiological Institute, University of Regensburg, University Street 31, 93053, Regensburg, Germany.
Background: Dystonia is a common neurological hyperkinetic movement disorder that can be caused by mutations in anoctamin 3 (ANO3, TMEM16C), a phospholipid scramblase and ion channel. We previously reported patients that were heterozygous for the ANO3 variants S651N, V561L, A599D and S651N, which cause dystonia by unknown mechanisms.
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İnönü University Faculty of Medicine, Deparment of Medical Microbiology, Malatya, Türkiye.
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bioRxiv
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Article Synopsis
- The RND superfamily of multidrug efflux systems is crucial for antibiotic resistance in gram-negative pathogens, specifically highlighting how the CmeABC system in a major enteric pathogen extrudes antibiotics.
- A new variant, RE-CmeABC, has emerged in clinical isolates, showing enhanced resistance due to specific amino acid changes in RE-CmeB and a promoter mutation, though the exact molecular mechanisms for its improvements are still unclear.
- RE-CmeABC is spreading globally among diverse strains, particularly associated with human infections, suggesting the variant's clinical significance, while evolutionary evidence hints at its origin and expansion driven by antibiotic selection pressure.
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