AI Article Synopsis
- This study aims to investigate if there’s a link between specific interleukin-8 receptor gene variations (CXCR1 and CXCR2) and the susceptibility to urinary tract infections (UTIs).
- Researchers reviewed multiple databases and included data from eight case-control studies involving over 4000 individuals to analyze the relationship between gene polymorphisms and UTIs.
- They found that the CXCR1 rs2234671 variant is associated with a higher risk of UTIs in children, particularly in those with acute pyelonephritis, suggesting that this gene variation could help predict UTI susceptibility in pediatric patients.
Article Abstract
Aim: The aim of this study was to determine whether a correlation exists between interleukin-8 receptor polymorphisms and urinary tract infection (UTI) susceptibility.
Methods: We systematically searched electronic databases including PubMed, Embase, China National Knowledge Infrastructure, and Web of Science up to 5 November 2017 to select appropriate studies that focused on C-X-C chemokine receptor type 1 and/or 2 (CXCR1, CXCR2) polymorphisms with susceptibility to UTI. Eight case-control studies including 2085 patients with UTI and 2012 controls were enrolled in this study. Seven studies of CXCR1 rs2234671 and two studies of rs3138086 were included in the meta-analyses. Pooled odds ratio (OR) and corresponding 95% confidence interval (CI) were synthesized using fixed-effects or random-effects model according to heterogeneity.
Results: No significant correlations were found between CXCR1 rs2234671 and rs3138086 polymorphisms and UTI susceptibility. However, subgroup analysis showed that rs2234671 was associated with an increased risk of UTI under allelic comparisons (C vs. G, OR = 1.95, 95% CI = 1.07-3.55), heterozygous model (GC vs. GG, OR = 1.93, 95% CI = 1.06-3.50), and dominant model (GC + CC vs. GG, OR = 1.98, 95% CI = 1.07-3.69) in children, especially in paediatric patients with acute pyelonephritis (allelic, OR = 2.43, 95% CI = 1.28-4.60; heterozygous, OR = 2.40, 95% CI = 1.24-4.62; dominant, OR = 2.48, 95% CI = 1.26-4.88). Furthermore, these results remained the same after eliminating paediatric patients with vesicoureteral reflux.
Conclusion: CXCR1 rs2234671 polymorphism might be associated with an increased risk of UTI in children.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1111/nep.13260 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Investigating the impact of the genetic variant CXCR1 (rs2234671) in individuals with urinary tract infections.
Hum Antibodies
April 2024
Department of Anatomy, Histology and Embryology, College of Veterinary Medicine, University of Al-Qadisiyah, Al-Qadisiyah, Iraq.
Background: Urinary tract infections (UTIs) are currently posing a worldwide health concern by affecting millions of people. The genetic variant rs2234671 in the CXCR1-interleukin-8 receptor is closely related to a raised UTI risk.
Objectives: In this work, the impact of CXCR1 (rs2234671) on UTI individuals was examined.
Genetic polymorphisms associated with urinary tract infection in children and adults: a systematic review and meta-analysis.
Am J Obstet Gynecol
June 2024
Department of Epidemiology and Biostatistics, Imperial College London, Norfolk Place, London, United Kingdom; Department of Urogynaecology, LNWH NHS Trust, London, United Kingdom; Department of Urogynaecology, Chelsea and Westminster NHS Foundation Trust, London, United Kingdom.
Article Synopsis
- The risk of urinary tract infections (UTIs) is highly hereditary, with lifetime susceptibility observed from childhood into adulthood, but there's a lack of comprehensive syntheses of genetic studies.
- This study systematically reviewed genetic polymorphisms linked to UTIs in both children and adults, assessing the strength and reliability of those associations.
- The analysis included 22 studies, finding notable associations with specific genetic variations (CXCR1, IL8, TGF, TLR4, and VDR) particularly in pediatric UTIs, and confirming CXCR1's link with adult UTIs as well.
Genetic Variant of CXCR1 (rs2234671) Associates with Clinical Outcome in Perihilar Cholangiocarcinoma.
Liver Cancer
April 2022
Department of Surgery and Transplantation, University Hospital RWTH Aachen, Aachen, Germany.
Background: Perihilar cholangiocarcinoma (pCCA) is a rare primary liver malignancy. Even in patients amenable to surgery, outcomes are often dismal. Here, we aimed to identify prognostic markers for patient outcomes by analyzing functionally relevant single-nucleotide polymorphisms (SNPs) in genes with a role in tumor inflammation and angiogenesis.
View Article and Find Full Text PDFValidation of Genetic Markers Associated with Survival in Colorectal Cancer Patients Treated with Oxaliplatin-Based Chemotherapy.
Cancer Epidemiol Biomarkers Prev
February 2022
Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Background: Associations between candidate genetic variants and treatment outcomes of oxaliplatin, a drug commonly used for colorectal cancer patients, have been reported but not robustly established. This study aimed to validate previously reported prognostic and predictive genetic markers for oxaliplatin treatment outcomes and evaluate additional putative functional variants.
Methods: Fifty-three SNPs were selected based on previous reports (40 SNPs) or putative function in candidate genes (13 SNPs).
The Relationship Between Chemokine and Chemokine Receptor Genes Polymorphisms and Chronic Obstructive Pulmonary Disease Susceptibility in Tatar Population from Russia: A Case Control Study.
Biochem Genet
February 2022
Department of Biology, Bashkir State Medical University, Lenina Str, 3, Ufa, 450008, Russian Federation.
Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory lung disease affecting primarily distal respiratory pathways and lung parenchyma. This study aimed to determine possible genetic association of chemokine and chemokine receptor genes polymorphisms with COPD in a Tatar population from Russia. SNPs of CCL20, CCR6, CXCL8, CXCR1, CXCR2, CCL8, CCL23, CCR2, and CX3CL1 genes and their gene-gene interactions were analyzed for association with COPD in cohort of 601 patients and 617 controls.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!