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A highly sensitive and selective fluorescent probe for fast sensing of endogenous HClO in living cells. | LitMetric
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A highly sensitive and selective fluorescent probe for fast sensing of endogenous HClO in living cells.

Changyu Zhang Qichang Nie Ismail Ismail Zhen Xi Long Yi

Chem Commun (Camb)

State Key Laboratory of Organic-Inorganic Composites and Beijing Key Laboratory of Bioprocess, Beijing University of Chemical Technology, Beijing 100029, China.

Published: April 2018

A new fluorescence probe was developed for HClO detection under physiological conditions, which displayed fast response (t1/2 < 30 s) and large off-on fluorescence increase (>1000-fold) toward HClO with high sensitivity and selectivity. The probe was successfully applied for the detection of both exogenous and endogenous HClO in living cells. Using the probe-based tool, we could observe the H2S-induced HClO biogenesis in living cells for the first time.

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 Source
http://dx.doi.org/10.1039/c8cc01917gDOI Listing

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