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A Bayesian Hybrid Design With Borrowing From Historical Study.
Pharm Stat
December 2024
Biostatistics, Daiichi Sankyo Inc, Basking Ridge, USA.
In early phase drug development of combination therapy, the primary objective is to preliminarily assess whether there is additive activity from a novel agent when combined with an established monotherapy. Due to potential feasibility issues for conducting a large randomized study, uncontrolled single-arm trials have been the mainstream approach in cancer clinical trials. However, such trials often present significant challenges in deciding whether to proceed to the next phase of development due to the lack of randomization in traditional two-arm trials.
View Article and Find Full Text PDFCombined interdisciplinary treatment of metastatic bone lesions using 3D robot-assisted image-guided navigation : Embolization, biopsy, ablation, and surgery in one operative session.
Oper Orthop Traumatol
December 2024
Department for Orthopaedic and Trauma Surgery, Lucerne Cantonal Hospital LUKS, Spitalstrasse, Lucerne, Switzerland.
Objective: To maximize local tumor control, stabilize affected bones, and preserve or replace joints with minimal interventional burden, thereby enhancing quality of life for empowered living.
Indications: Suitable for patients with bone metastases, particularly those with severe pain and/or fractures and appropriate life expectancy.
Contraindications: In primary bone tumors, refer to the sarcoma surgery team for evaluation of wide resection.
A spatio-temporal graph wavelet neural network (ST-GWNN) for association mining in timely social media data.
Sci Rep
December 2024
Henan University of Engineering, Zhengzhou, 451191, China.
Social media generates vast amounts of spatio-temporal sequential data. However, current methods often ignore the complex spatio-temporal correlations within these data. This oversight makes it difficult to fully capture the dynamic features of the data.
View Article and Find Full Text PDFA novel recyclable hydrolyzed nanomagnetic copolymer catalyst for green, and one-pot synthesis of tetrahydrobenzo[b]pyrans.
Sci Rep
December 2024
Department of Organic Chemistry, Faculty of Chemistry, University of Mazandaran, Babolsar, Iran.
Polymer-based catalysts have garnered significant interest for their efficiency, reusability, and compatibility with various synthesis processes. In catalytic applications, polymers offer the advantage of structural versatility, enabling functional groups to be tailored for specific catalytic activities. In this study, we developed a novel magnetic copolymer of methyl methacrylate and maleic anhydride (PMMAn), synthesized via in situ chemical polymerization of methyl methacrylate onto maleic anhydride, using benzoyl peroxide as a free-radical initiator.
View Article and Find Full Text PDFHeuristic-based vehicle arrangement for ro-ro ships.
Sci Rep
December 2024
Information Science and Engineering School, Northeastern University, Shenyang, 110819, Liaoning, China.
In this paper, a two-level search strategy fused with an improved no-fit polygon algorithm and improved bat algorithm is proposed to obtain the layout points of multiple vehicles. Additionally, a space-time scheduling strategy is proposed using the Improved D*Lite Algorithm (ID*Lite) and improved Bezier curve to generate the trajectories of individual vehicles. Furthermore, a conflict resolution strategy is introduced to address the collision conflict problem during multi-vehicle scheduling.
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