Systems biology for nursing in the era of big data and precision health.

Background: The systems biology framework was previously synthesized with the person-environment-health-nursing metaparadigm.

Purpose: The purpose of this paper is to present a nursing discipline-specific perspective of the association of systems biology with big data and precision health.

Method: The fields of systems biology, big data, and precision health are now overviewed, from origins through expansions, with examples of what is being done by nurses in each area of science.

Discussion: Technological advances continue to expand omics and other varieties of big data that inform the person's phenotype and health outcomes for precision care. Meanwhile, millions of participants in the United States are being recruited for health-care research initiatives aimed at building the information commons of digital health data.

Conclusions: Implications and opportunities abound via conceptualizing the integration of these fields through the nursing metaparadigm.