This paper presents a novel two-wired active electrode that achieves ultrahigh input impedance using power supply bootstrapping. The proposed circuit reduces the input capacitance of a buffer amplifier while enabling measurements using leads with only two wires, providing a low-complexity and low-cost solution for interference rejection and artifact reduction in dc-coupled dry-contact biopotential measurements. An implemented prototype shows that, even using standard operational amplifiers, an input capacitance as low as 71 fF can be obtained, maintaining a high impedance in a 0-1 kHz bandwidth, sufficient for ECG, EEG, and EMG measurements. The circuit has a simple and easily replicable implementation that requires no individual adjustment. A common mode rejection ratio (CMRR) above 103 dB at 50 Hz was achieved and the increased rejection to interference due to the potential divider effect was experimentally tested maintaining a 92-dB CMRR at 50 Hz with a 1.2-M source impedance unbalance. ECG measurements were conducted to validate the active electrode against a traditional alternative, and a test with dry-contact EEG electrodes was successfully conducted. Although the proposed circuit is intended to acquire superficial electrophysiological signals using dry electrodes, it can be used for measurement from other high-impedance sources, such as micropipette electrodes.
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http://dx.doi.org/10.1109/TBCAS.2018.2796581 | DOI Listing |
Dalton Trans
January 2025
Department of Chemistry, Indian Institute of Technology Roorkee, Roorkee, 247667, India.
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View Article and Find Full Text PDFFront Immunol
January 2025
Department of Nephrology, Sir Run Run Hospital, Nanjing Medical University, Nanjing, Jiangsu, China.
Rationale: Acute kidney injury (AKI) is a clinical syndrome associated with a multitude of conditions. Although renal replacement therapy (RRT) remains the cornerstone of treatment for advanced AKI, its implementation can potentially pose risks and may not be readily accessible across all healthcare settings and regions. Elevated lactate levels are implicated in sepsis-induced AKI; however, it remains unclear whether increased lactate directly induces AKI or elucidates the underlying mechanisms.
View Article and Find Full Text PDFBioact Mater
April 2025
Department of Orthopaedics, Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Shanghai Institute of Traumatology and Orthopaedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2nd Road, Shanghai, 200025, PR China.
Bioelectrical stimulation is a powerful technique used to promote tissue regeneration, but it can be hindered by an "electrical overload" phenomenon in the core region of stimulation. We develop a threaded microneedle electrode system that protects against "electrical overload" by delivering medicinal hydrogel microspheres into the core regions. The threaded needle body is coated with polydopamine and chitosan to enhance the adhesion of microspheres, which are loaded into the threaded grooves, allowing for their stereoscopic release in the core regions.
View Article and Find Full Text PDFJ Microbiol Biotechnol
November 2024
Department of Biotechnology and Department of Integrative Food, Bioscience and Biotechnology (BK21 FOUR), Chonnam National University, Gwangju 61186, Republic of Korea.
This study investigates the modulatory effects of nicergoline, a major bioactive compound derived from ergot fungus, on the 5-hydroxytryptamine 3A (5-HT3A) receptor. Utilizing a two-electrode voltage-clamp technique, we evaluated the impact of nicergoline on the 5-HT-induced inward current (I) in 5-HT3A receptors. Our findings reveal that nicergoline inhibits I in a reversible and concentration-dependent manner.
View Article and Find Full Text PDFLangmuir
January 2025
College of Textile Science and Engineering, Jiangnan University, 1800 Lihu Road, 214122 Wuxi, P. R. China.
In the realm of zinc-air batteries, high bifunctional catalytic efficacy is intimately tied to the evaluation of catalysts. Consequently, the pursuit of proficient bifunctional catalysts that can efficiently catalyze both the oxygen reduction reaction (ORR) and oxygen evolution reaction (OER) remains a paramount objective in this research area. In this study, the spiny cobalt tetroxide (CoO) encapsulated hollow carbon spheres (HCSs) are constructed by anchoring CoO onto HCS via hydrothermal or annealing treatment.
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