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| http://dx.doi.org/10.1002/ajh.25094 | DOI Listing |
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Fetal bradycardia and acidosis during maternal parenteral iron: Case reports and literature review.
Int J Gynaecol Obstet
January 2025
Department of Obstetrics and Gynaecology, Pamela Youde Nethersole Eastern Hospital, Chai Wan, Hong Kong.
Article Synopsis
- Iron deficiency anemia is a significant concern for pregnant women, leading to the increased use of intravenous (IV) iron infusions, despite debate over the need for fetal monitoring during treatment.
- Two cases were reported where pregnant women experienced fetal bradycardia shortly after receiving iron isomaltoside infusions, along with respiratory issues, which necessitated emergency cesarean sections.
- The research indicates that while fetal bradycardia related to IV iron is rare, it is a potential risk even in healthy pregnancies, suggesting that fetal monitoring during infusions should be reconsidered.
Dissimilar ferric derisomaltose formulations - In vitro comparisons between an originator and its intended similars.
Eur J Pharm Biopharm
October 2024
Department of Medicine, Georgetown University School of Medicine, Washington, DC, USA. Electronic address:
Background: The complex nature of intravenous (IV) iron formulations makes manufacturing and characterising similars challenging. This study examined whether simple in vitro tests can distinguish the high-dose IV iron formulation, Monofer® (ferric derisomaltose [FDI]), from the first intended copies of FDI, Rapifer® (FDI intended similar A [FDIIS-A]) and Tosiron® (FDI intended similar B [FDIIS-B]), approved in India and Pakistan, respectively. Neither intended similar is available in Europe or the United States.
View Article and Find Full Text PDFIs It Time to Alter the Standard of Care for Iron Deficiency/Iron Deficiency Anemia in Reproductive-Age Women?
Biomedicines
January 2024
Department of Global Affairs, Thomas Jefferson University, Philadelphia, PA 19107, USA.
Two billion people worldwide suffer from anemia, with reproductive-age women being disproportionately affected. Iron plays a crucial role in cellular function and impacts cognition, physical function, and quality of life. Iron deficiency (ID) and iron deficiency anemia (IDA) are associated with adverse effects on pregnancy and fetal development.
View Article and Find Full Text PDFComparison of iron isomaltoside ferumoxytol with iron sucrose for iron deficiency anemia: a meta-analysis of randomized controlled trials.
Afr Health Sci
September 2023
Department of hematological oncology chemotherapy, Fenghua District People's Hospital of Ningbo, Zhejiang, China.
Introduction: The efficacy of iron isomaltoside ferumoxytol versus iron sucrose to treat iron deficiency anemia remains controversial. We conduct this meta-analysis to explore the influence of iron isomaltoside ferumoxytol versus iron sucrose on iron deficiency anemia.
Methods: We have searched PubMed, EMbase, Web of science, EBSCO, and Cochrane library databases through March 2021 for randomized controlled trials (RCTs) assessing the effect of iron isomaltoside ferumoxytol versus iron sucrose on iron deficiency anemia.
Effect of NF-κβ inhibitor - dehydroxymethylepoxyquinomicin on iron isomaltoside toxicity toward peritoneal mesothelial cells.
Ren Fail
December 2024
Department of Molecular Target Medicine Screening, Aichi Medical University School of Medicine, Nagakute, Japan.
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