Evaluation of - and -based pharmacogenetic algorithm for warfarin dose in Gaza-Palestine.

Aim: To evaluate applicability of , and based algorithm to predict warfarin stable dose (WSD) in a group of Palestinian patients.

Patients & Methods: Warfarin doses were retrospectively calculated for 101 Palestinian patients under warfarin therapy using three models. Performance of the three models was assessed in 47 patients found to take WSD.

Results: Frequency of , and alleles is 13.6, 0.0 and 46.5% respectively. The international warfarin pharmacogenetics consortium algorithm was more reliable (MAE = 8.9 ± 1.4; R = 0.350) than both the clinical algorithm (MAE = 10.4 ± 1.4; R = 0.128;) and the fixed-dose algorithm (MAE = 11.1 ± 1.7).

Conclusion: The international warfarin pharmacogenetics consortium algorithm can be reliably applied for predicting the WSD in Palestinian population.