Uterine tumors resembling ovarian sex cord tumors are rare neoplasms with varied histological and immunophenotypic profile, uncertain histiogenesis and biological behavior. A critical evaluation of histological features is essential for diagnosis and management of these cases.
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Risk Stratification of Miscellaneous Uterine Mesenchymal Neoplasms: The Role of Morphology, Immunohistochemistry, and Molecular Testing.
Adv Anat Pathol
January 2025
Department of Pathology and Laboratory Medicine, Weill Cornell Medicine/New York-Presbyterian Hospital, New York, NY.
Uterine mesenchymal tumors are a diverse group of tumors that can display a broad range of morphologic, immunohistochemical, and molecular profiles and are associated with varied clinical behaviors. In recent years, they have increasingly been classified by their underlying molecular alterations, leading to a more precise separation of diagnostic entities. As their diagnostic criteria have been refined, so too have the features that can be used to predict clinical outcomes.
View Article and Find Full Text PDFST-Segment Elevation: Hypocalcemia or Takotsubo Syndrome? A Diagnostic Dilemma.
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December 2024
Cardiology Unit, Interdisciplinary Department of Medicine, University of Bari Aldo Moro, University Hospital Consortium, Polyclinic of Bari, Bari, Italy.
A wide range of etiologies, both ischemic and nonischemic, can produce an electrocardiographic pattern of ST-segment elevation (STE), including Takotsubo syndrome (TTS) and electrolyte imbalances. Instances of hypocalcemia-induced TTS and STE are exceedingly rare in medical literature. This paper presents the case of a 75-year-old woman with advanced ovarian cancer and no prior heart issues, who exhibited diffuse STE on electrocardiogram, resembling acute coronary syndrome.
View Article and Find Full Text PDFThe Vaginal Microbiome and Reproductive Health in Adolescents and Adults.
J Pediatr Adolesc Gynecol
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Pediatric Neuroendocrinology Group, Clinical Research Branch, National Institute of Environmental Health Sciences (NIEHS), Durham, NC 27709. Electronic address:
Study Objective: The aim of this paper is to review our understanding of the vaginal microbiome (VM), the internal and external factors that influence its composition, and how it relates to adult and adolescent reproductive health.
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[Recurrent uterine tumour resembling ovarian sex-cord tumor with GREB1::NCOA1 fusion gene: report of a case].
Zhonghua Bing Li Xue Za Zhi
December 2024
Department of Pathology, Hubei Cancer Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan430079, China.
[Clinicopathological significance of SOX2 and FOXG1 expression patterns in ovarian immature teratomas].
Zhonghua Bing Li Xue Za Zhi
December 2024
Department of Pathology, Third Hospital, School of Basic Medical Sciences, Peking University Health Science Center, Beijing100191, China.
To investigate the relationship between the expression patterns of SOX2 and FOXG1 and the differentiation/development level of neural components in immature teratoma and to determine the clinical significance and potential application of this correlation in a clinical setting. We conducted a comprehensive whole transcriptome sequencing analysis to identify differentially expressed genes (DEGs) across various subtypes of ovarian germ cell tumors. Additionally, immunohistochemical staining of paraffin-embedded tissue sections was employed to assess the nuclear staining pattern of SOX2 and FOXG1 proteins within the tumor tissues.
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