Exfoliation syndrome (XFS) is a systemic disease with significant ocular manifestations, including glaucoma and cataract. The disease impacts close to 70 million people globally and is now recognised as the most common identifiable cause of open-angle glaucoma. Since the discovery of XFS 100 years ago by Dr John G. Lindberg, there has been considerable advancement in understanding its pathogenesis and resulting clinical implications. The purpose of this paper is to summarise information regarding the epidemiology, pathophysiology, ocular manifestations and systemic associations of XFS with the objective of sharing clinical pearls to assist in early detection and enhanced management of patients.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1136/bjophthalmol-2017-311321 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
The Ocular Surface and the Anterior Segment of the Eye in the Pseudoexfoliation Syndrome: A Comprehensive Review.
Int J Mol Sci
January 2025
NDDH, Royal Devon University Healthcare NHS Foundation Trust, Barnstaple EX31 4JB, UK.
Pseudoexfoliation syndrome (PXS) is an age-related fibrillopathy where fibrillar exfoliation material accumulates and deposits in ocular and extra-ocular tissue. Within the eye, this substance accumulates on the ocular surface and in the anterior segment of the eye, impacting ocular structures such as the conjunctiva, Tenon's capsule, sclera, cornea, iris, ciliary body, trabecular meshwork, and lens. This review aims to collate the current literature on how each anatomical part of the eye is affected by PXS, with a strong focus on molecular changes.
View Article and Find Full Text PDFComparison of glaucoma progression rate in glaucoma patients at different stages using guided progression analysis with optical coherence tomography.
BMC Ophthalmol
January 2025
Department of Ophthalmology, University of Health Sciences, Izmir Bozyaka Education and Research Hospital, Bahar Mah. Saim Çıkrıkcı Cad No: 59, Karabağlar, Turkey.
Background: The aim of the present study was to compare the rates of change in Ganglion Cell- Inner Plexiform Layer (GCIPL) and Retinal Nerve Fiber Layer (RNFL) thickness, as measured by Optical Coherence Tomography (OCT) Guided Progression Analysis (GPA) program in control group, Primary Open Angle Glaucoma (POAG) and Pseudoexfoliation Glaucoma (PXG) eyes.
Methods: 60 POAG and 60 PXG patients and 30 control group patients were included in the study. Patients diagnosed with glaucoma were divided into two groups as mild (Mean deviation (MD) > -6.
Trabecular meshwork ultrastructural changes in primary and secondary glaucoma.
Sci Rep
January 2025
Ophthalmic Pathology Laboratory, L V Prasad Eye Institute, Kallam Anji Reddy Campus, 500034, Hyderabad, India.
To examine ultrastructural changes in the trabecular meshwork (TM) in patients with primary and secondary glaucoma using scanning electron microscopy (SEM). This was a qualitative descriptive hospital-based study on the ultrastructure of the TM. Pure TM samples were collected after microincisional trabeculectomy from 26 patients with primary or secondary glaucoma and 10 control samples from eye bank donor corneas.
View Article and Find Full Text PDFAbandoned Cataract Surgeries: An Analysis of Surgical Referrals to a Tertiary Eye Center.
Cureus
November 2024
Ophthalmology, All India Institute of Medical Sciences, New Delhi, IND.
Purpose: This study aims to analyze the outcomes of cases of abandoned cataract surgeries referred to a tertiary eye center.
Methods: This retrospective observational case series includes eleven cases referred to a tertiary eye center following abandoned cataract surgeries. The preoperative factors, intraoperative management, and postoperative outcomes were recorded and analyzed.
The role of serum biomarkers in determining systemic inflammation and cardiovascular risk in pseudoexfoliation syndrome.
Int Ophthalmol
December 2024
Department of Ophthalmology, Beypazari State Hospital, Ankara, Turkey.
Purpose: To investigate the role of hematological and atherogenic biomarkers in evaluating systemic inflammation and cardiovascular risk in patients with pseudoexfoliation syndrome.
Methods: This retrospective study included 200 patients, 90 with pseudoexfoliation (PEX) syndrome (Group 1) and 110 healthy controls (Group 2). Twelve-hour fasting blood samples were collected to measure complete blood count, neutrophil/lymphocyte ratio (NLR), monocyte/lymphocyte ratio (MLR), platelet/lymphocyte ratio (PLR), systemic immune-inflammation index (SII) (neutrophil x platelet/lymphocyte), systemic inflammatory response index (SIRI) (neutrophil x monocyte/lymphocyte), pan-immune inflammation value (PIV) (neutrophil x platelet x monocyte/lymphocyte), C-reactive protein (CRP), uric acid, glucose, triglycerides (TG), total cholesterol, HDL, LDL, non-HDL, and triglyceride-glucose (TyG) index (Ln (TG [mg/dL] × glucose [mg/dL]/2)).
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!