AI Article Synopsis
- A specialized reconstruction method combining low rank and sparse techniques was developed to accelerate dynamic 2D and 3D hyperpolarized C MRI using balanced steady-state free precession sequence.
- The methods were validated with in vivo data from normal rats and tumor-bearing mice, allowing for up to four-fold acceleration in isotropic 3D dynamic acquisitions and two-fold acceleration in 2D dynamic acquisitions.
- This acceleration enabled detailed visualization of the biodistribution of various compounds, like [2-C]pyruvate and [1-C]lactate, in critical organs and tumors, along with the calculation of high-resolution T maps.
Article Abstract
Acceleration of dynamic 2D (T Mapping) and 3D hyperpolarized C MRI acquisitions using the balanced steady-state free precession sequence was achieved with a specialized reconstruction method, based on the combination of low rank plus sparse and local low rank reconstructions. Methods were validated using both retrospectively and prospectively undersampled in vivo data from normal rats and tumor-bearing mice. Four-fold acceleration of 1-2 mm isotropic 3D dynamic acquisitions with 2-5 s temporal resolution and two-fold acceleration of 0.25-1 mm 2D dynamic acquisitions was achieved. This enabled visualization of the biodistribution of [2-C]pyruvate, [1-C]lactate, [C, N]urea, and HP001 within heart, kidneys, vasculature, and tumor, as well as calculation of high resolution T maps.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6054792 | PMC |
| http://dx.doi.org/10.1016/j.jmr.2018.03.006 | DOI Listing |
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