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Impact of meningococcal vaccination on carriage and disease transmission: A review of the literature. | LitMetric

Impact of meningococcal vaccination on carriage and disease transmission: A review of the literature.

Hum Vaccin Immunother

a Medical Development , Scientific & Clinical Affairs, Pfizer Vaccines, Pfizer Inc , Collegeville, PA , USA.

Published: May 2018

AI Article Synopsis

Article Abstract

Colonization of the human nasopharyngeal tract by the bacterium Neisseria meningitidis is usually asymptomatic, but life-threatening meningococcal disease with a clinical presentation of meningitis, septicemia, or more rarely, gastrointestinal symptoms, can develop. Invasive meningococcal disease (IMD) can be fatal within 24 hours, but IMD is vaccine-preventable. Vaccines used to protect against IMD caused by 5 of the 6 most common serogroups (A, B, C, W, and Y) may also influence carriage prevalence in vaccinated individuals. Lower carriage among vaccinated people may reduce transmission to nonvaccinated individuals to provide herd protection against IMD. This article reviews observational and clinical studies examining effects of vaccination on N. meningitidis carriage prevalence in the context of mass vaccination campaigns and routine immunization programs. Challenges associated with carriage studies are presented alongside considerations for design of future studies to assess the impact of vaccination on carriage.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5989891PMC
http://dx.doi.org/10.1080/21645515.2018.1454570DOI Listing

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