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ALK-rearranged, CD34-positive spindle cell neoplasms resembling dermatofibrosarcoma protuberans: a study of seven cases.
Histopathology
October 2024
Department of Anatomic Pathology, Cleveland Clinic, Cleveland, OH, USA.
Aims: The majority of dermatofibrosarcoma protuberans (DFSP) harbour PDGFB or PDGFD rearrangements. We encountered ALK expression/rearrangement in a PDGFB/D-negative CD34-positive spindle cell neoplasm with features similar to DFSP, prompting evaluation of ALK-rearrangements in DFSP and plaque-like CD34-positive dermal fibroma (P-LDF).
Methods And Results: We searched the archives of academic institutions for cases previously coded as DFSP and P-LDF.
Plaque-like ALK-positive cutaneous inflammatory myofibroblastic tumor.
G Ital Dermatol Venereol
April 2018
Department of Dermatology and Venereology, IRCCS Istituto Ortopedico Galeazzi, University of Milan, Milan, Italy.
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