AI Article Synopsis
- Migratory dendritic cell (DC) subsets transport tissue antigens to draining lymph nodes, which can either trigger or downregulate T cell immune responses.
- In a mouse model of skin-specific self-antigen expression, CD103 dermal DCs actively move from the skin to skin draining lymph nodes within 48 hours after antigen introduction, primarily activating local effector T cells during this window.
- The study emphasizes that the signals from skin-resident T cells are essential for the migration of CD103 DCs and the development of a strong autoimmune reaction, while signals from T cells in the draining lymph nodes do not influence DC migration.
Article Abstract
Migratory dendritic cell (DC) subsets deliver tissue Ags to draining lymph nodes (DLNs) to either initiate or inhibit T cell-mediated immune responses. The signals mediating DC migration in response to tissue self-antigen are largely unknown. Using a mouse model of inducible skin-specific self-antigen expression, we demonstrate that CD103 dermal DCs (DDCs) rapidly migrate from skin to skin DLN (SDLNs) within the first 48 h after Ag expression. This window of time was characterized by the preferential activation of tissue-resident Ag-specific effector T cells (Teffs), with no concurrent activation of Ag-specific Teffs in SDLNs. Using genetic deletion and adoptive transfer approaches, we show that activation of skin-resident Teffs is required to drive CD103 DDC migration in response to tissue self-antigen and this Batf3-dependent DC population is necessary to mount a fulminant autoimmune response in skin. Conversely, activation of Ag-specific Teffs in SDLNs played no role in DDC migration. Our studies reveal a crucial role for skin-resident T cell-derived signals, originating at the site of self-antigen expression, to drive DDC migration during the elicitation phase of an autoimmune response.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5916499 | PMC |
| http://dx.doi.org/10.4049/jimmunol.1701206 | DOI Listing |
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