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Huanglian Ganjiang Decoction alleviates DSS-induced colitis through suppressing inflammation and protecting intestinal barrier: from the perspective of disassembling prescriptions.
J Ethnopharmacol
January 2025
School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou 510006, China. Electronic address:
Ethnopharmacological Relevance: Huanglian Ganjiang decoction (HGD), which is composed of Chinese medicines with cold, warm, and astringent properties, has demonstrated significant therapeutic efficacy in ulcerative colitis (UC). However, the underlying mechanisms remain unclear, highlighting the need for a multi-faceted investigation. Disassembling prescriptions is a crucial approach for investigating compatibility mechanisms.
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Alzheimers Dement
December 2024
Global Brain Health Institute, Trinity College Dublin, Dublin, Ireland; School of Medicine and Global Brain Health Institute, Trinity College Dublin, Dublin, Ireland.
Context: The development of new effective and sustainable dementia care interventions requires active engagement of all service users in research studies. This ensures that interventions are tailored to meet individual needs and preferences. Here, we describe modelling and development of a multi-faceted sensory health support intervention for residents with dementia in long-term care, co-designed with dementia care users and their supporters.
View Article and Find Full Text PDFHospital to home transition of children with medical complexities in the Netherlands: current practice.
Eur J Pediatr
January 2025
Department of Neonatal & Pediatric Intensive Care, Division of Pediatric Intensive Care, Erasmus Medical Center - Sophia Children's Hospital, Rotterdam, The Netherlands.
Children with Medical Complexity (CMC) often require 24/7 expert care, which may impede discharge from hospital to home (H2H) resulting in prolonged admission. Limited research exists on pediatric patients with delayed discharges and the underlying reasons for such extended admissions. Therefore, our objectives were to (1) describe the demographics, clinical characteristics, and course of CMC who are in their H2H transition and (2) identify the reasons for postponement of H2H discharge.
View Article and Find Full Text PDFGenome-Wide Identification and Analysis of Glycosyltransferases in .
Microorganisms
December 2024
College of Plant Protection, Henan Agricultural University, Zhengzhou 450002, China.
Corn leaf blight and stem rot caused by are significant diseases that severely affect corn crops. Glycosyltransferases (GTs) catalyze the transfer of sugar residues to diverse receptor molecules, participating in numerous biological processes and facilitating functions ranging from structural support to signal transduction. This study identified 101 genes through functional annotation of the TZ-3 genome.
View Article and Find Full Text PDFBreast cancer is a significant health challenge worldwide, and disproportionately affects women of African ancestry (AA) who experience higher mortality rates relative to other racial/ethnic groups. Several studies have pointed to biological factors that affect breast cancer outcomes. A recently discovered stromal cell population that expresses P ROCR, Z EB1 and P DGFRα (PZP cells) was found to be enriched in normal healthy breast tissue from AA donors, and only in tumor adjacent tissues from donors of European ancestry (EA).
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